| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Geriatrics (Drs. Solfrizzi, Panza, Colacicco, D’Introno, C. Capurso, Torres, and A. Capurso), Center for Aging Brain, Memory Unit, University of Bari, Italy; Department of Geriatrics (Dr. C. Capurso), University of Foggia, Italy; Institute of Hygiene (Dr. Grigoletto), University of Padua, Italy; National Research Council of Italy (Dr. Maggi), CNR, Center on Aging, Padua; National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (Dr. Del Parigi), Phoenix, AZ; Department of Psychiatry (Dr. Reiman), University of Arizona, Tucson; Department of Neurology (Dr. Caselli), Mayo Clinic, Scottsdale, AZ; and Laboratory of Epidemiology and Biostatistics (Dr. Scafato and G. Farchi), Istituto Superiore di Sanità, Rome, Italy.
Address correspondence and reprint requests to Dr. Vincenzo Solfrizzi, Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11-70124 Bari, Italy; e-mail: v.solfrizzi{at}geriatria.uniba.it
Objective: To estimate prevalence, incidence, and rate of progression of mild cognitive impairment (MCI) to dementia and correlated vascular risk factors with incident MCI and its progression to dementia.
Methods: The authors evaluated 2,963 individuals from the population-based sample of 5,632 subjects 65 to 84 years old, at the first (1992 to 1993) and second survey (1995 to 1996) of the Italian Longitudinal Study on Aging (ILSA), with a 3.5-year follow-up. Dementia, Alzheimer disease (AD), vascular dementia (VaD), other types of dementia, and MCI were classified using current clinical criteria.
Results: Among the 2,963 participants, 139 MCI patients were diagnosed at the first ILSA survey. During the 3.5-year follow-up, 113 new events of MCI were diagnosed with an estimated incidence rate of 21.5 per 1,000 person-years. We found a progression rate to dementia (all causes) of 3.8/100 person-years. Specific progression rates for AD, VaD, and other types of dementia were 2.3, 1.3, and 0.3/100 person-years. Furthermore, age was a risk factor for incident MCI (RR: 5.93, 95% CI: 3.17 to 11.10), while education was protective (RR: 0.06, 95% CI: 0.03 to 0.10), and serum total cholesterol evidenced a borderline nonsignificant trend for a protective effect. There was a nonsignificant trend for stroke as a risk factor of progression of MCI to dementia.
Conclusions: In this population, among those who progressed to dementia, 60% progressed to AD and 33% to VaD. Vascular risk factors influence incident mild cognitive impairment and the rate of progression to dementia.
Received April 19, 2004. Accepted in final form July 22, 2004.
*Members of the Italian Longitudinal Study on Aging Working Group are listed in the Appendix on page 1890.
This article has been cited by other articles:
|
|
 |
|
  F. Panza, C. Capurso, A. D'Introno, A. M. Colacicco, A. Santamato, A. Capurso, and V. Solfrizzi Hypertension and Mild Cognitive Impairment Subtypes Arch Neurol, July 1, 2008; 65(7): 992 - 993. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Caracciolo, K. Palmer, R. Monastero, B. Winblad, L. Backman, and L. Fratiglioni Occurrence of cognitive impairment and dementia in the community: A 9-year-long prospective study Neurology, May 6, 2008; 70(19_Part_2): 1778 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Anstey, D. M. Lipnicki, and L.-F. Low Cholesterol as a Risk Factor for Dementia and Cognitive Decline: A Systematic Review of Prospective Studies With Meta-Analysis Am J Geriatr Psychiatry, May 1, 2008; 16(5): 343 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. M. Brust A 74-Year-Old Man With Memory Loss and Neuropathy Who Enjoys Alcoholic Beverages JAMA, March 5, 2008; 299(9): 1046 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Raina, P. Santaguida, A. Ismaila, C. Patterson, D. Cowan, M. Levine, L. Booker, and M. Oremus Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline Ann Intern Med, March 4, 2008; 148(5): 379 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Solfrizzi, E. Reiman, R. J. Caselli, A. Del Parigi, A. Capurso, F. Panza, A. D. Carlo, M. Baldereschi, and D. Inzitari CIND AND MCI IN THE ITALIAN ELDERLY: FREQUENCY, VASCULAR RISK FACTORS, PROGRESSION TO DEMENTIA Neurology, December 4, 2007; 69(23): 2186 - 2187. [Full Text] [PDF]
|
|
|
|
|
|
C. Reitz, M.-X. Tang, J. Manly, R. Mayeux, and J. A. Luchsinger Hypertension and the Risk of Mild Cognitive Impairment Arch Neurol, December 1, 2007; 64(12): 1734 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Schretlen, A. B. Inscore, T. D. Vannorsdall, M. Kraut, G. D. Pearlson, B. Gordon, and H. A. Jinnah Serum uric acid and brain ischemia in normal elderly adults Neurology, October 2, 2007; 69(14): 1418 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. L. Lopez, L. H. Kuller, and J. T. Becker Progression to Dementia in Probable and Possible Mild Cognitive Impairment Reply Arch Neurol, August 1, 2007; 64(8): 1210 - 1211. [Full Text] [PDF]
|
|
|
|
|
|
F. Panza, C. Capurso, A. D'Introno, A. M. Colacicco, A. Santamato, A. Capurso, and V. Solfrizzi Progression to Dementia in Probable and Possible Mild Cognitive Impairment Arch Neurol, August 1, 2007; 64(8): 1209 - 1210. [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Wilson, J. A. Schneider, S. E. Arnold, Y. Tang, P. A. Boyle, and D. A. Bennett Olfactory Identification and Incidence of Mild Cognitive Impairment in Older Age Arch Gen Psychiatry, July 1, 2007; 64(7): 802 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Das, P. Bose, A. Biswas, A. Dutt, T. K. Banerjee, A. Hazra, D. K. Raut, A. Chaudhuri, and T. Roy An epidemiologic study of mild cognitive impairment in Kolkata, India Neurology, June 5, 2007; 68(23): 2019 - 2026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-C. Liu, P.-N. Wang, H.-C. Wang, K.-N. Lin, C.-J. Hong, C.-Y. Liu, and P.-H. Tsai Conversion to Dementia From Questionable Dementia in an Ethnic Chinese Population J Geriatr Psychiatry Neurol, June 1, 2007; 20(2): 76 - 83. [Abstract] [PDF]
|
|
|
|
 |
|
 S. L. Tyas, J. C. Salazar, D. A. Snowdon, M. F. Desrosiers, K. P. Riley, M. S. Mendiondo, and R. J. Kryscio Transitions to Mild Cognitive Impairments, Dementia, and Death: Findings from the Nun Study Am. J. Epidemiol., June 1, 2007; 165(11): 1231 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Solfrizzi, A. D'Introno, A. M. Colacicco, C. Capurso, A. Del Parigi, G. Baldassarre, P. Scapicchio, E. Scafato, M. Amodio, A. Capurso, et al. Alcohol consumption, mild cognitive impairment, and progression to dementia Neurology, May 22, 2007; 68(21): 1790 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Panza, C. Capurso, A. D'Introno, A. M. Colacicco, M. Chirico, A. Capurso, V. Solfrizzi, and R. O'Brien EFFECT OF A CLINICAL STROKE ON THE RISK OF DEMENTIA IN A PROSPECTIVE COHORT Neurology, May 15, 2007; 68(20): 1748 - 1749. [Full Text] [PDF]
|
|
|
|
|
|
A. S. Fleisher, B. B. Sowell, C. Taylor, A. C. Gamst, R. C. Petersen, L. J. Thal, and for the Alzheimer's Disease Cooperative Study Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment Neurology, May 8, 2007; 68(19): 1588 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Panza, C. Capurso, A. D'Introno, A. M. Colacicco, A. Capurso, V. Solfrizzi, P. J. Visser, A. Kester, J. Jolles, and F. Verhey Ten-year risk of dementia in subjects with mild cognitive impairment Neurology, April 10, 2007; 68(15): 1238 - 1239. [Full Text] [PDF]
|
|
|
|
|
|
F. Panza, C. Capurso, A. D'Introno, A. M. Colacicco, A. Capurso, V. Solfrizzi, P. A. Boyle, and D. A. Bennett Mild cognitive impairment: Risk of Alzheimer disease and rate of cognitive decline Neurology, March 20, 2007; 68(12): 964 - 965. [Full Text] [PDF]
|
|
|
|
|
|
O. L. Lopez, L. H. Kuller, J. T. Becker, C. Dulberg, R. A. Sweet, H. M. Gach, and S. T. DeKosky Incidence of Dementia in Mild Cognitive Impairment in the Cardiovascular Health Study Cognition Study Arch Neurol, March 1, 2007; 64(3): 416 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Staessen, T. Richart, and W. H. Birkenhager Less Atherosclerosis and Lower Blood Pressure for a Meaningful Life Perspective With More Brain Hypertension, March 1, 2007; 49(3): 389 - 400. [Full Text] [PDF]
|
|
|
|
|
|
A. L. Hunderfund, R. O. Roberts, T. C. Slusser, C. L. Leibson, Y. E. Geda, R. J. Ivnik, E. G. Tangalos, and R. C. Petersen Mortality in amnestic mild cognitive impairment: A prospective community study Neurology, November 28, 2006; 67(10): 1764 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gamaldo, A. Moghekar, S. Kilada, S. M. Resnick, A. B. Zonderman, and R. O'Brien Effect of a clinical stroke on the risk of dementia in a prospective cohort Neurology, October 24, 2006; 67(8): 1363 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Visser, A. Kester, J. Jolles, and F. Verhey Ten-year risk of dementia in subjects with mild cognitive impairment. Neurology, October 10, 2006; 67(7): 1201 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Panza, C. Capurso, and V. Solfrizzi Stroke and memory decline: a question of degenerative or vascular origin. Arch Neurol, September 1, 2006; 63(9): 1347 - 1348. [Full Text] [PDF]
|
|
|
|
|
|
P. A. Boyle, R. S. Wilson, N. T. Aggarwal, Y. Tang, and D. A. Bennett Mild cognitive impairment: Risk of Alzheimer disease and rate of cognitive decline Neurology, August 8, 2006; 67(3): 441 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Reitz, J. A. Luchsinger, M.-X. Tang, J. Manly, and R. Mayeux Stroke and memory performance in elderly persons without dementia. Arch Neurol, April 1, 2006; 63(4): 571 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hall, J. Murrell, A. Ogunniyi, M. Deeg, O. Baiyewu, S. Gao, O. Gureje, J. Dickens, R. Evans, V. Smith-Gamble, et al. Cholesterol, APOE genotype, and Alzheimer disease: An epidemiologic study of Nigerian Yoruba Neurology, January 24, 2006; 66(2): 223 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Panza, A. D'Introno, A. M. Colacicco, C. Capurso, A. Del Parigi, R. J. Caselli, A. Pilotto, G. Argentieri, P. L. Scapicchio, E. Scafato, et al. Current Epidemiology of Mild Cognitive Impairment and Other Predementia Syndromes Am J Geriatr Psychiatry, August 1, 2005; 13(8): 633 - 644. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
