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This Article Figures Only Full Text Full Text (PDF) CME: Take the course for this article: Volume 63, Number 10, November 23, 2004 Correspondence: Submit a response Correspondence: View responses Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maramattom, B. V. Articles by Wijdicks, E. F.M. Search for Related Content PubMed PubMed Citation Articles by Maramattom, B. V. Articles by Wijdicks, E. F.M. Related Collections All Toxicology Critical care Related Article

Sirolimus may not cause neurotoxicity in kidney and liver transplant recipients

From the Division of Critical Care Neurology, Department of Neurology, Mayo Clinic, Rochester, MN.

Address correspondence and reprint requests to Dr. Boby V. Maramattom, Flat 18, Kairali Apartments, Panampally Nagar, Kochi, Ke, India; e-mail: Maramattom.Boby{at}mayo.edu

Neurotoxicity associated with calcineurin inhibitors cyclosporin A and tacrolimus is established. Sirolimus is a new agent related to tacrolimus, but its mechanism of action differs. The authors reviewed 202 transplant recipients treated with sirolimus from 2001 to 2004. They found no evidence of neurotoxicity with sirolimus therapy for up to 18 months (range, 15 days to 3 years). Sirolimus could be considered a substitute immunosuppressant for patients with cyclosporin A or tacrolimus neurotoxicity.

Received April 16, 2004. Accepted in final form July 9, 2004.

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