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NEUROLOGY 2004;63:1966-1967
© 2004 American Academy of Neurology
Brief Communications

CSF characteristics in early-onset multiple sclerosis

D. Pohl, MD, K. Rostasy, MD, H. Reiber, PhD and F. Hanefeld, MD

From the Department of Pediatrics and Pediatric Neurology (Drs. Pohl, Rostasy, and Hanefeld) and Neurochemistry Laboratory, Department of Neurology (Dr. Reiber), Georg-August-University Goettingen, Germany.

Address correspondence and reprint requests to Dr. Daniela Pohl, Department of Pediatrics and Pediatric Neurology, Georg-August-University Goettingen, Robert-Koch-Strasse 40, 37075 Goettingen, Germany; e-mail: dpohl{at}med.uni-goettingen.de

The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood–CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.

Received April 9, 2004. Accepted in final form July 6, 2004.




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