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NEUROLOGY 2004;63:2162-2164
© 2004 American Academy of Neurology
Brief Communications

Essential tremor

Occupational exposures to manganese and organic solvents

E. D. Louis, MD, MS, L. M. Applegate, BA, P. Factor-Litvak, PhD, M. K. Parides, PhD and L. Andrews, DrPH

From the Gertrude H. Sergievsky Center (Dr. Louis and L.M. Applegate), Taub Institute for Research on Alzheimer’s Disease and the Aging Brain (Dr. Louis), and Department of Neurology (Dr. Louis), College of Physicians and Surgeons, Columbia University; and Departments of Epidemiology (Dr. Factor-Litvak), Biostatistics (Dr. Parides), and Environmental Health Sciences (Dr. Andrews), Mailman School of Public Health, Columbia University, New York, NY.

Address correspondence and reprint requests to Dr. Elan Louis, Unit 198, Neurological Institute, 710 West 168th Street, New York, NY 10032; e-mail: EDL2{at}columbia.edu

Occupational exposures to manganese and organic solvents cause parkinsonism as well as prominent action tremor, resembling essential tremor (ET), yet their association with ET has not been studied. These chemicals cause cerebellar pathology. Cerebellar changes have been linked with ET. Using lifetime occupational histories, the authors demonstrated that occupational exposures were similar in cases and controls, which does not support an etiologic link between occupational exposures to these chemicals and ET.

Received April 23, 2004. Accepted in final form July 22, 2004.




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