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From the VaudGeneva Deep Brain Stimulation Program for Movement Disorders, CHUV, Lausanne, Switzerland.
Address correspondence and reprint requests to Dr. J. Ghika, Department of Neurology, CHUV, BH 13, CH-1011 Lausanne, Switzerland; e-mail: joseph.ghika{at}chuv.hospvd.ch
The authors observed a high rate of suicide (6/140 patients, 4.3%) in a large cohort of patients with movement disorders treated with deep brain stimulation (DBS). Apparent risk factors included a previous history of severe depression and multiple successive DBS surgeries, whereas there was no relationship with the underlying condition, DBS target, electrical parameters, or modifications of treatment. Paradoxically, all patients experienced an excellent motor outcome following the procedure. The authors propose that patients at high risk for suicide should be excluded from DBS surgery.
Received January 31, 2004. Accepted in final form July 16, 2004.
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