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NEUROLOGY 2004;63:2178-2179
© 2004 American Academy of Neurology


Brief Communications

Rituximab stabilizes multifocal motor neuropathy increasingly less responsive to IVIg

Stephan J. Rüegg, MD, Peter Fuhr, MD and Andreas J. Steck, MD

From the Department of Neurology, University Hospital, Basel, Switzerland.

Address correspondence and reprint requests to Dr. Stephan Rüegg, Department of Neurology, University Hospital, Petersgraben 4, CH-4031 Basel, Switzerland; e-mail: srueegg{at}uhbs.ch

The authors report a patient with anti-GM1 antibody-negative multifocal motor neuropathy (MMN) who was increasingly less responsive to IV immunoglobulins (IVIgs). Five yearly courses of the monoclonal anti-CD20 antibody rituximab were well tolerated and extended the interval of IVIg administration from 7 to 12 days (corresponding to 42% reduction of IVIg) during this period. Rituximab may be a benefit for patients with MMN.


Received May 17, 2004. Accepted in final form July 22, 2004.

Presented in part at the annual meeting of the Swiss Society for Clinical Neurophysiology, Basel, Switzerland, April 22–24, 2004.




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