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NEUROLOGY 2004;63:2184-2186
© 2004 American Academy of Neurology
Brief Communications

An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome

S. Chiba, MD, PhD, T. Sugiyama, MD, PhD, K. Yonekura, MD, S. Tanaka, MD, PhD, H. Matsumoto, MD, PhD, N. Fujii, BS, PhD, S. Yokota, BS, PharmD and T. Hirayama, BAgr, PhD

From the Departments of Neurology (Drs. Chiba, Yonekura, Tanaka, and Matsumoto) and Microbiology (Drs. Fujii and Yokota), School of Medicine, Sapporo Medical University; Department of Gastroenterology (Dr. Sugiyama), Hokkaido University Graduate School of Medicine, Sapporo; and Institute of Tropical Medicine (Dr. Hirayama), Nagasaki University, Japan.

Address correspondence and reprint requests to Dr. Susumu Chiba, Department of Neurology School of Medicine, Sapporo Medical University, Minami 1-Jo Nishi 16 chome, Chuo-ku, Sapporo 060–8543, Japan; e-mail: chiba{at}sapmed.ac.jp

The authors examined antibodies against native vacuolating cytotoxin (VacA) of Helicobacter pylori in CSF from 12 patients with Miller-Fisher syndrome (MFS). The VacA protein was separated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis and Western blotting analysis was carried out. Eight of 12 MFS patients had a specific immunoglobulin G antibody against VacA in the CSF. There is sequence homology between VacA and some membrane ion transport proteins, raising the possibility that A-VacA-Ab involves the ion channels in the node of Ranvier in some patients with MFS.

Received December 9, 2003. Accepted in final form July 22, 2004.






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