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| Neurology supplements are not peer-reviewed. Information contained in Neurology supplements represent the opinions of the authors and are not endorsed by nor do they reflect the views of the American Academy of Neurology, Editor-in-Chief, or Associate Editors of Neurology. |
From the Peachtree Neurological Clinic (Dr. Stuart), Atlanta, Georgia, and the Department of Neurology (Dr. Vermersch), Hôpital R. Salengro, CHRU of Lille, France.
Address correspondence and reprint requests to Dr. William H. Stuart, Peachtree Neurological Clinic, 3200 Downwood Circle, Suite 550, Atlanta, GA 30327; e-mail: whstuart{at}aol.com
Interferon beta (IFNß) is the first-line treatment for patients diagnosed with multiple sclerosis (MS). In patients with MS who experience breakthrough disease while receiving treatment with IFNß, it is common clinical practice to administer additional therapeutic agents. The rationale for use of concomitant therapies in the long-term management of MS is derived from the heterogeneous and multifactorial etiology of this disease. Agents used concomitantly have the potential to exert synergistic effects and slow the progression of disease in patients who experience breakthrough disease. Concomitant therapies that have been reported in patients with MS are reviewed here.
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