HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Correale, J. Articles by Fiol, M. Search for Related Content PubMed PubMed Citation Articles by Correale, J. Articles by Fiol, M. Related Collections All Immunology Autoimmune diseases Multiple sclerosis Devic's syndrome

Activation of humoral immunity and eosinophils in neuromyelitis optica

From Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.

Address correspondence and reprint requests to Dr. Jorge Correale, Raúl Carrea Institute for Neurological Research, FLENI, Montañeses 2325 (1428), Buenos Aires, Argentina; e-mail: jcorreale{at}fleni.org.ar

Objective: To study immunologic alterations in patients with neuromyelitis optica (NMO).

Methods: The authors studied 8 patients with NMO together with 16 healthy subjects, 16 patients with relapsing remitting multiple sclerosis (RRMS), and 16 patients with secondary progressive MS (SPMS), matched for age and sex, as controls. Because recent histopathologic studies have demonstrated that active NMO lesions consist of perivascular immunoglobulin (Ig) deposition and eosinophil infiltration, IL-5, IL-6, IL-12, IgG, and IgM production by anti-myelin oligodendrocyte glycoprotein (MOG) mononuclear cells in peripheral blood and CSF were selected for study using ELISPOT. Eotaxin-2 (Eo-2) and eotaxin-3 (Eo-3) levels were also assessed using ELISA and eosinophil cationic protein (ECP) levels by radioimmunoassay.

Results: MOG-specific responses in CSF showed significant increase in IL-5, IL-6, IgG, and IgM secreting cells in NMO patients compared with patients with RRMS, SPMS and healthy subjects. Interestingly, numbers of IgM secreting cells were significantly higher than identical specificity IgG secreting ones. Moreover, CSF Eo-2, Eo-3, and ECP levels were also significantly higher in NMO patients compared to all three control populations. Anti-MOG IL-12 secreting cells were increased in CSF and peripheral blood from NMO, RRMS, and SPMS patients when compared to healthy subjects.

Conclusions: These observations suggest that neuromyelitis optica is associated with a major humoral immune response (particularly anti-MOG IgM production) and eosinophil activation present exclusively in CSF.

Received April 9, 2004. Accepted in final form September 3, 2004.

This article has been cited by other articles:

				R. M. Sappington and D. J. Calkins Contribution of TRPV1 to Microglia-Derived IL-6 and NF{kappa}B Translocation with Elevated Hydrostatic Pressure Invest. Ophthalmol. Vis. Sci., July 1, 2008; 49(7): 3004 - 3017. [Abstract] [Full Text] [PDF]

				C. S. Yu, C. Z. Zhu, K. C. Li, Y. Xuan, W. Qin, H. Sun, and P. Chan Relapsing Neuromyelitis Optica and Relapsing-Remitting Multiple Sclerosis: Differentiation at Diffusion-Tensor MR Imaging of Corpus Callosum Radiology, July 1, 2007; 244(1): 249 - 256. [Abstract] [Full Text] [PDF]

				I Nozaki, T Hamaguchi, K Komai, and M Yamada Fulminant Devic disease successfully treated by lymphocytapheresis J. Neurol. Neurosurg. Psychiatry, September 1, 2006; 77(9): 1094 - 1095. [Full Text] [PDF]

				J. Correale and S. N Tenembaum Myelin basic protein and myelin oligodendrocyte glycoprotein T-cell repertoire in childhood and juvenile multiple sclerosis Multiple Sclerosis, August 1, 2006; 12(4): 412 - 420. [Abstract] [PDF]

				C.S. Yu, F.C. Lin, K.C. Li, T.Z. Jiang, C.Z. Zhu, W. Qin, H. Sun, and P. Chan Diffusion tensor imaging in the assessment of normal-appearing brain tissue damage in relapsing neuromyelitis optica. AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1009 - 1015. [Abstract] [Full Text] [PDF]