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NEUROLOGY 2004;63:2426-2428
© 2004 American Academy of Neurology
Brief Communications

Peri-ictal SPECT and surgical treatment for intractable epilepsy related to schizencephaly

G. D. Cascino, MD, J. R. Buchhalter, MD, PhD, J. I. Sirven, MD, E. L. So, MD, J. F. Drazkowski, MD, R. S. Zimmerman, MD and C. Raffel, MD, PhD

From the Departments of Neurology (Drs. Cascino, Buchhalter, Sirven, So, and Drazkowski) and Neurosurgery (Drs. Zimmerman and Raffel), Mayo Clinic Rochester (Drs. Cascino, Buchhalter, So, and Raffel), MN; and Mayo Clinic Scottsdale (Drs. Sirven, Drazkowski, and Zimmerman), AZ.

Address correspondence and reprint requests to Dr. Gregory D. Cascino, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; e-mail: gcascino{at}mayo.edu

The authors evaluated four patients with schizencephaly who underwent subtraction ictal SPECT coregistered to MRI (SISCOM) prior to epilepsy surgery. Three patients had a SISCOM alteration that was concordant with the epileptic brain tissue. Two of these patients were rendered seizure-free and one individual experienced a significant reduction in seizures. The patient with an indeterminate SISCOM had an unfavorable outcome. SISCOM is useful in evaluating patients with schizencephaly for epilepsy surgery.

Received May 18, 2004. Accepted in final form August 3, 2004.






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