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Prevalence of migraine on each day of the natural menstrual cycle

From the City of London Migraine Clinic and Departments of Gynaecology and Sexual Health (Dr. MacGregor), St. Bartholomew’s Hospital; and Cancer Research UK and University College London Cancer Trials Centre (A. Hackshaw), UK.

Address correspondence and reprint requests to Dr. E.A. MacGregor, City of London Migraine Clinic, 22 Charterhouse Square, London EC1M 6DX, UK.

Diary data from 155 women were analyzed using within-woman analysis. Compared with all other times of the cycle, migraine was 1.7 times more likely to occur during the 2 days before menstruation and 2.1 times more likely to be severe and 2.5 times more likely to occur during the first 3 days of menstruation and 3.4 times more likely to be severe. This confirms that migraine at menstruation is different from nonmenstrual attacks, even within individuals.

Received January 8, 2004. Accepted in final form March 2, 2004.

See also pages 202 and 261

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