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NEUROLOGY 2004;63:362-363
© 2004 American Academy of Neurology
Brief Communications

Fragile X premutation alleles in SCA, ET, and parkinsonism in an Asian cohort

E. K. Tan, MD MRCP, Y. Zhao, MD PhD, K. Y. Puong, MS, H. Y. Law, PhD, L. L. Chan, FRCR, K. Yew, BS, C. Tan, BS, H. Shen, PhD, V. R. Chandran, PhD, M. L. Teoh, MD, Y. Yih, MD, R. Pavanni, MD, M. C. Wong, FRCP and I. S. Ng, MD

From the Departments of Neurology (Drs. E.K. Tan, Shen, Pavanni, Wong, and Ng, and C. Tan, K. Yew, ), Clinical Research (Drs. Zhao and Chandran, K.Y. Puong), Diagnostic Radiology (Dr. Chan), and Health Screening (Drs. Teoh and Yih), Singapore General Hospital, National Neuroscience Institute (Drs. E.K. Tan, Pavanni, and Wong), SingHealth Research (Dr. E.K. Tan), and K.K. Women and Children Hospital (Dr. Ng), Singapore.

Address correspondence and reprint requests to Dr. E.K. Tan, Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608; e-mail: gnrtek{at}sgh.com.sg

Among 367 subjects, the authors analyzed 167 patients with essential tremor, sporadic progressive cerebellar ataxia, multiple-system atrophy, and atypical parkinsonism and 200 healthy control subjects for FMR1 premutation alleles. None of the subjects carried alleles within the premutation range. These findings suggest that in the absence of other supportive clinical or imaging features, the cost-effectiveness of routine fragile X tremor/ataxia syndrome screening in this Asian cohort with movement disorders was low.

Received February 4, 2004. Accepted in final form March 8, 2004.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the July 27 issue to find the title link for this article.




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