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NEUROLOGY 2004;63:373-375
© 2004 American Academy of Neurology
Brief Communications

Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy

Caterina Cerminara, MD, Maria Lucia Montanaro, MD, Paolo Curatolo, MD and Stefano Seri, MD

From the Department of Developmental Neurology and Psychiatry, Division of Neurosciences, "Tor Vergata" University, Rome, Italy.

Address correspondence and reprint requests to Dr. Stefano Seri, Neurosciences Division, "Tor Uvergata" University, Via di S. Angela Merici 96, 00162, Rome, Italy; e-mail: Stefano.Seri{at}uniroma2.it

The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.

Received November 26, 2003. Accepted in final form March 10, 2004.




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