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NEUROLOGY 2004;63:376-378
© 2004 American Academy of Neurology
Brief Communications

L-Dopa responsiveness in dementia with Lewy bodies, Parkinson disease with and without dementia

S. B. Bonelli, MD, G. Ransmayr, MD, M. Steffelbauer, MD, T. Lukas, MD, C. Lampl, MD and M. Deibl, PhD

From the Department of Neurology and Psychiatry (Drs. Bonelli, Ransmayr, Steffelbauer, Lukas, and Lampl), Linz General Hospital; and Department of Biostatistics (Dr. Deibl), Innsbruck Medical University, Austria.

Address correspondence and reprint requests to Univ.-Prof. Dr. Gerhard Ransmayr, Linz General Hospital, Krankenhausstrasse 9, A-4020 Linz, Austria; e-mail: gerhard.ransmayr{at}akh.linz.at

The authors analyzed whether nondemented (PD) and demented Parkinson patients (PDD) and patients with dementia with Lewy bodies (DLB) respond similarly in the levodopa test (LDT). Percentage of motor improvement was similar in the three groups; the proportion of patients with 10% and more improvement was greater in PD than in PDD and DLB. Positive LDT was predictive for favorable response in chronic levodopa treatment, but also some nonresponsive demented patients profited from chronic levodopa therapy.

Received November 25, 2003. Accepted in final form March 12, 2004.




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