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 Volume 63, Number 3, August 10, 2004
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NEUROLOGY 2004;63:436-442
© 2004 American Academy of Neurology

Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease

R. J. Castellani, MD, M. Colucci, MD, Z. Xie, MD, W. Zou, MD, C. Li, MD, P. Parchi, MD, S. Capellari, MD, M. Pastore, PhD, M. H. Rahbar, PhD, S. G. Chen, PhD and P. Gambetti, MD

From the National Prion Disease Pathology Surveillance Center, Division of Neuropathology, Institute of Pathology (Drs. Castellani, Xie, Zou, Li, Pastore, Chen, and Gambetti), Case Western Reserve University, Cleveland, OH; Department of Epidemiology & Data Coordinating Center (Dr. Rahbar), Michigan State University, East Lansing, MI; Department of Neurology (Dr. Colucci), Sciences and Vision, University of Genoa, Italy; and Department of Neurological Sciences (Drs. Parchi and Capellari), University of Bologna, Italy.

Address correspondence and reprint requests to Dr. Pierluigi Gambetti, Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106; email: pxg13{at}po.cwru.edu

Background: The increase of the 14-3-3 protein in CSF is used as a diagnostic test in Creutzfeldt-Jakob disease (CJD), but the sensitivity and specificity of the 14-3-3 test are disputed. One reason for the dispute may be the recently established heterogeneity of sporadic CJD. The relationship between CSF 14-3-3 protein and sporadic CJD subtypes, distinguished by electrophoretic mobility of proteinase K-resistant prion protein (PrPSc) and genotype at codon 129 of the prion protein gene, has not been elucidated.

Methods: The authors examined the 14-3-3 protein test in 90 patients with sporadic CJD. PrPSc type (type 1 or type 2) and the genotype at polymorphic codon 129 were determined in each patient. Mutations were excluded by prion gene sequencing.

Results: The authors’ findings indicate that the sensitivity of the 14-3-3 test is higher in patients with molecular features of the classic sporadic CJD than in patients with the nonclassic CJD subtypes. The difference appears to be related to the PrPSc type and not to the codon 129 genotype. Disease duration before 14-3-3 testing might also have an influence because it was shorter in classic sporadic CJD.

Conclusion: The Creutzfeldt-Jakob disease clinical subtype should be considered when interpreting results of the 14-3-3 test.

Received July 2, 2003. Accepted in final form May 14, 2004.

See also pages 410, 443, and 450


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