Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow CME: Take the course for this article:
 Volume 63, Number 3, August 10, 2004
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Related articles in Neurology
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Castellani, R. J.
Right arrow Articles by Gambetti, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Castellani, R. J.
Right arrow Articles by Gambetti, P.
Related Collections
Right arrow Diagnostic test assessment
Right arrow Prion
NEUROLOGY 2004;63:436-442
© 2004 American Academy of Neurology

Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease

R. J. Castellani, MD, M. Colucci, MD, Z. Xie, MD, W. Zou, MD, C. Li, MD, P. Parchi, MD, S. Capellari, MD, M. Pastore, PhD, M. H. Rahbar, PhD, S. G. Chen, PhD and P. Gambetti, MD

From the National Prion Disease Pathology Surveillance Center, Division of Neuropathology, Institute of Pathology (Drs. Castellani, Xie, Zou, Li, Pastore, Chen, and Gambetti), Case Western Reserve University, Cleveland, OH; Department of Epidemiology & Data Coordinating Center (Dr. Rahbar), Michigan State University, East Lansing, MI; Department of Neurology (Dr. Colucci), Sciences and Vision, University of Genoa, Italy; and Department of Neurological Sciences (Drs. Parchi and Capellari), University of Bologna, Italy.

Address correspondence and reprint requests to Dr. Pierluigi Gambetti, Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106; email: pxg13{at}po.cwru.edu

Background: The increase of the 14-3-3 protein in CSF is used as a diagnostic test in Creutzfeldt-Jakob disease (CJD), but the sensitivity and specificity of the 14-3-3 test are disputed. One reason for the dispute may be the recently established heterogeneity of sporadic CJD. The relationship between CSF 14-3-3 protein and sporadic CJD subtypes, distinguished by electrophoretic mobility of proteinase K-resistant prion protein (PrPSc) and genotype at codon 129 of the prion protein gene, has not been elucidated.

Methods: The authors examined the 14-3-3 protein test in 90 patients with sporadic CJD. PrPSc type (type 1 or type 2) and the genotype at polymorphic codon 129 were determined in each patient. Mutations were excluded by prion gene sequencing.

Results: The authors’ findings indicate that the sensitivity of the 14-3-3 test is higher in patients with molecular features of the classic sporadic CJD than in patients with the nonclassic CJD subtypes. The difference appears to be related to the PrPSc type and not to the codon 129 genotype. Disease duration before 14-3-3 testing might also have an influence because it was shorter in classic sporadic CJD.

Conclusion: The Creutzfeldt-Jakob disease clinical subtype should be considered when interpreting results of the 14-3-3 test.

Received July 2, 2003. Accepted in final form May 14, 2004.

See also pages 410, 443, and 450


Related articles in Neurology:

Advances in diagnosing Creutzfeldt-Jakob disease with MRI and CSF 14-3-3 protein analysis
Martin Zeidler and Alison Green
Neurology 2004 63: 410-411. [Full Text]  



This article has been cited by other articles:


Home page
 Age AgeingHome page
S. Jayaratnam, A. K. L. Khoo, and D. Basic
Rapidly progressive Alzheimer's disease and elevated 14-3-3 proteins in cerebrospinal fluid
Age Ageing, July 1, 2008; 37(4): 467 - 469.
[Full Text] [PDF]

Home page
 Age AgeingHome page
M. Foundas, M. D. Donaldson, I. L. McAllister, and L. R. Bridges
Vision loss due to coincident ocular and central causes in a patient with Heidenhain variant Creutzfeldt-Jakob disease
Age Ageing, March 1, 2008; 37(2): 231 - 232.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Brown
Transmissible spongiform encephalopathy in the 21st century: Neuroscience for the clinical neurologist
Neurology, February 26, 2008; 70(9): 713 - 722.
[Full Text] [PDF]

Home page
 BrainHome page
U. Heinemann, A. Krasnianski, B. Meissner, D. Varges, K. Kallenberg, W. J. Schulz-Schaeffer, B. J. Steinhoff, E. M. Grasbon-Frodl, H. A. Kretzschmar, and I. Zerr
Creutzfeldt-Jakob disease in Germany: a prospective 12-year surveillance
Brain, May 1, 2007; 130(5): 1350 - 1359.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Krasnianski, W. J. Schulz-Schaeffer, K. Kallenberg, B. Meissner, D. A. Collie, S. Roeber, M. Bartl, U. Heinemann, D. Varges, H. A. Kretzschmar, et al.
Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD
Brain, September 1, 2006; 129(9): 2288 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. J. Collins, P. Sanchez-Juan, C. L. Masters, G. M. Klug, C. van Duijn, A. Poleggi, M. Pocchiari, S. Almonti, N. Cuadrado-Corrales, J. de Pedro-Cuesta, et al.
Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease
Brain, September 1, 2006; 129(9): 2278 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Sanchez-Juan, A. Green, A. Ladogana, N. Cuadrado-Corrales, R. Saanchez-Valle, E. Mitrovaa, K. Stoeck, T. Sklaviadis, J. Kulczycki, K. Hess, et al.
CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease.
Neurology, August 22, 2006; 67(4): 637 - 643.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Arata, H. Takashima, R. Hirano, H. Tomimitsu, K. Machigashira, K. Izumi, M. Kikuno, A. R. Ng, F. Umehara, T. Arisato, et al.
Early clinical signs and imaging findings in Gerstmann-Straussler-Scheinker syndrome (Pro102Leu)
Neurology, June 13, 2006; 66(11): 1672 - 1678.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. Krasnianski, B. Meissner, W. Schulz-Schaeffer, K. Kallenberg, M. Bartl, U. Heinemann, D. Varges, H. A. Kretzschmar, and I. Zerr
Clinical features and diagnosis of the MM2 cortical subtype of sporadic Creutzfeldt-Jakob disease.
Arch Neurol, June 1, 2006; 63(6): 876 - 880.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
B. Meissner, I. M. Westner, K. Kallenberg, A. Krasnianski, M. Bartl, D. Varges, C. Bosenberg, H. A. Kretzschmar, M. Knauth, W. J. Schulz-Schaeffer, et al.
Sporadic Creutzfeldt-Jakob disease: Clinical and diagnostic characteristics of the rare VV1 type
Neurology, November 22, 2005; 65(10): 1544 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
V. Lewis, A. F. Hill, G. M. Klug, A. Boyd, C. L. Masters, and S. J. Collins
Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles
Neurology, July 12, 2005; 65(1): 113 - 118.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
T. Hamaguchi, T. Kitamoto, T. Sato, H. Mizusawa, Y. Nakamura, M. Noguchi, Y. Furukawa, C. Ishida, I. Kuji, K. Mitani, et al.
Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease
Neurology, February 22, 2005; 64(4): 643 - 648.
[Abstract] [Full Text] [PDF]

Home page
 JWatch NeurologyHome page
Consider CJD Phenotype When Interpreting 14-3-3 Test
Journal Watch Neurology, November 29, 2004; 2004(1129): 2 - 2.
[Full Text]

Home page
 NeurologyHome page
M. Zeidler and A. Green
Advances in diagnosing Creutzfeldt-Jakob disease with MRI and CSF 14-3-3 protein analysis
Neurology, August 10, 2004; 63(3): 410 - 411.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by AAN Enterprises, Inc.