| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Neurology (Drs. Shiga, Miyazawa, and Itoyama), Tohoku University School of Medicine, Department of Neurology (Dr. S. Sato), Kohnan Hospital, Second Department of Internal Medicine (Dr. Fukushima), Hiraka General Hospital, Department of Neurology (Dr. Shibuya), Miyagi National Hospital, Department of Neurology (Dr. Y. Sato), Research Institute for Brain and Blood Vessels, Akita, Department of Neurology (Dr. Konno), Nishitaga National Hospital, Department of Neuropathology (Dr. Doh-ura), Institute of Brain Diseases, Kyushu University Faculty of Medicine, and Department of Diagnostic Radiology (Drs. Mugikura, Tamura, Higano, and Takahashi), Tohoku University School of Medicine, Japan.
Address correspondence and reprint requests to Dr. Y. Shiga, Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; e-mail: yshiga{at}em.neurol.med.tohoku.ac.jp
Objective: To evaluate the usefulness of diffusion-weighted MRI (DWI) for the early diagnosis of Creutzfeldt–Jakob disease (CJD).
Methods: Thirty-six consecutive patients (age 56 to 82 years) were enrolled, and 26 were examined by DWI. Nine were definite based on the World Health Organization criteria, and 27 were probable. The percentages of DWI abnormalities, periodic sharp wave complexes (PSWCs) on the EEG, detection of CSF 14-3-3 protein, and increase of CSF neuron-specific enolase (>25 ng/mL) on the first examination were compared. For DWI, 32 patients (age 31 to 84 years) who showed progressive dementia or impaired consciousness served as disease controls.
Results: The percentage of DWI abnormalities was 92.3%, of PSWCs 50.0%, of 14-3-3 protein detection 84.0%, and of NSE increase 73.3%. Two of the 32 control subjects were falsely positive on DWI. The sensitivity of DWI was 92.3% (95% CI 74.8 to 99.5%) and specificity 93.8% (95% CI 79.2 to 99.2%). In 17 patients who did not show PSWCs on the first EEG, abnormal DWI findings were still clearly detected. Four patients who were negative for 14-3-3 protein also showed DWI abnormalities. DWI abnormalities were detected as early as at 3 weeks of symptom duration in four patients in whom PSWCs were not yet evident.
Conclusions: DWI can detect characteristic lesions in the majority of patients with CJD regardless of the presence of PSWCs. DWI was the most sensitive test for the early clinical diagnosis of CJD; consideration should be given to its inclusion in the clinical diagnostic criteria of CJD.
Received April 16, 2003. Accepted in final form March 18, 2004.
See also pages 410, 436, and 450
Presented in part at the 127th Annual Meeting of the American Neurologic Association, October 14, 2002, New York.
This article has been cited by other articles:
|
|
 |
|
  B. Meissner, K. Kallenberg, P. Sanchez-Juan, D. Collie, D. M. Summers, S. Almonti, S. J. Collins, P. Smith, P. Cras, G. H. Jansen, et al. MRI lesion profiles in sporadic Creutzfeldt-Jakob disease Neurology, June 9, 2009; 72(23): 1994 - 2001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Manners, P. Parchi, C. Tonon, S. Capellari, R. Strammiello, C. Testa, G. Tani, E. Malucelli, C. Spagnolo, P. Cortelli, et al. Pathologic correlates of diffusion MRI changes in Creutzfeldt-Jakob disease Neurology, April 21, 2009; 72(16): 1425 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Klug, H. Wand, A. Boyd, M. Law, S. Whyte, J. Kaldor, C. L. Masters, and S. Collins Enhanced geographically restricted surveillance simulates sporadic Creutzfeldt-Jakob disease cluster Brain, February 1, 2009; 132(2): 493 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Fujita, S Nakane, M Harada, Y Izumi, and R Kaji Diffusion tensor imaging in patients with Creutzfeldt-Jakob disease J. Neurol. Neurosurg. Psychiatry, November 1, 2008; 79(11): 1304 - 1306. [Full Text] [PDF]
|
|
|
|
 |
|
 R.K. Fulbright, C. Hoffmann, H. Lee, A. Pozamantir, J. Chapman, and I. Prohovnik MR Imaging of Familial Creutzfeldt-Jakob Disease: A Blinded and Controlled Study AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1638 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Geschwind, K. M. Tan, V. A. Lennon, R. F. Barajas Jr, A. Haman, C. J. Klein, S. A. Josephson, and S. J. Pittock Voltage-Gated Potassium Channel Autoimmunity Mimicking Creutzfeldt-Jakob Disease Arch Neurol, October 1, 2008; 65(10): 1341 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Meissner, K. Kallenberg, P. Sanchez-Juan, A. Krasnianski, U. Heinemann, D. Varges, M. Knauth, and I. Zerr Isolated Cortical Signal Increase on MR Imaging as a Frequent Lesion Pattern in Sporadic Creutzfeldt-Jakob Disease AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): 1519 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Haik, D. Galanaud, M. G. Linguraru, K. Peoc'h, N. Privat, B. A. Faucheux, N. Ayache, J.-J. Hauw, D. Dormont, and J.-P. Brandel In Vivo Detection of Thalamic Gliosis: A Pathoradiologic Demonstration in Familial Fatal Insomnia Arch Neurol, April 1, 2008; 65(4): 545 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.S. Seo, K.-H. Chang, D.G. Na, B.J. Kwon, and D.H. Lee High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2 AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 458 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Brown Transmissible spongiform encephalopathy in the 21st century: Neuroscience for the clinical neurologist Neurology, February 26, 2008; 70(9): 713 - 722. [Full Text] [PDF]
|
|
|
|
|
|
M Furtner, E Gelpi, S Kiechl, M Knoflach, A Zangerl, T Gotwald, J Willeit, H Maier, T Strobel, U Unterberger, et al. Iatrogenic Creutzfeldt Jakob disease 22 years after human growth hormone therapy: clinical and radiological features J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 229 - 231. [Full Text] [PDF]
|
|
|
|
|
|
M. D. Geschwind, K. A. Josephs, J. E. Parisi, and B. M. Keegan A 54-year-old man with slowness of movement and confusion Neurology, November 6, 2007; 69(19): 1881 - 1887. [Full Text] [PDF]
|
|
|
|
|
|
M. Noguchi-Shinohara, T. Hamaguchi, T. Kitamoto, T. Sato, Y. Nakamura, H. Mizusawa, and M. Yamada Clinical features and diagnosis of dura mater graft-associated Creutzfeldt-Jakob disease Neurology, July 24, 2007; 69(4): 360 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R G Macfarlane, S J Wroe, J Collinge, T A Yousry, and H R Jager Neuroimaging findings in human prion disease J. Neurol. Neurosurg. Psychiatry, July 1, 2007; 78(7): 664 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.J. Tschampa, K. Kallenberg, H.A. Kretzschmar, B. Meissner, M. Knauth, H. Urbach, and I. Zerr Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1114 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamamoto, M. Kinoshita, S. Furukawa, and K. Kajiyama Early Abnormality of Diffusion-Weighted Magnetic Resonance Imaging Followed by Brain Atrophy in a Case of Gerstmann-Straussler-Scheinker Disease Arch Neurol, March 1, 2007; 64(3): 450 - 451. [Full Text] [PDF]
|
|
|
|
|
|
A. Krasnianski, W. J. Schulz-Schaeffer, K. Kallenberg, B. Meissner, D. A. Collie, S. Roeber, M. Bartl, U. Heinemann, D. Varges, H. A. Kretzschmar, et al. Clinical findings and diagnostic tests in the MV2 subtype of sporadic CJD Brain, September 1, 2006; 129(9): 2288 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Collins, P. Sanchez-Juan, C. L. Masters, G. M. Klug, C. van Duijn, A. Poleggi, M. Pocchiari, S. Almonti, N. Cuadrado-Corrales, J. de Pedro-Cuesta, et al. Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease Brain, September 1, 2006; 129(9): 2278 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Keyrouz, B. T. Labib, and R. Sethi MRI and EEG findings in Heidenhain variant of Creutzfeldt-Jakob disease. Neurology, July 25, 2006; 67(2): 333 - 333. [Full Text] [PDF]
|
|
|
|
|
|
H. Arata, H. Takashima, R. Hirano, H. Tomimitsu, K. Machigashira, K. Izumi, M. Kikuno, A. R. Ng, F. Umehara, T. Arisato, et al. Early clinical signs and imaging findings in Gerstmann-Straussler-Scheinker syndrome (Pro102Leu) Neurology, June 13, 2006; 66(11): 1672 - 1678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Krasnianski, B. Meissner, W. Schulz-Schaeffer, K. Kallenberg, M. Bartl, U. Heinemann, D. Varges, H. A. Kretzschmar, and I. Zerr Clinical features and diagnosis of the MM2 cortical subtype of sporadic Creutzfeldt-Jakob disease. Arch Neurol, June 1, 2006; 63(6): 876 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. -P. Landolt, M. Glatzel, T. Blattler, P. Achermann, C. Roth, J. Mathis, J. Weis, I. Tobler, A. Aguzzi, and C. L. Bassetti Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease Neurology, May 9, 2006; 66(9): 1418 - 1424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Lewis, M. Yu, S. J. DeArmond, W. P. Dillon, B. L. Miller, and M. D. Geschwind Human Growth Hormone-Related Iatrogenic Creutzfeldt-Jakob Disease With Abnormal Imaging Arch Neurol, February 1, 2006; 63(2): 288 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Meissner, I. M. Westner, K. Kallenberg, A. Krasnianski, M. Bartl, D. Varges, C. Bosenberg, H. A. Kretzschmar, M. Knauth, W. J. Schulz-Schaeffer, et al. Sporadic Creutzfeldt-Jakob disease: Clinical and diagnostic characteristics of the rare VV1 type Neurology, November 22, 2005; 65(10): 1544 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Tschampa, K. Kallenberg, H. Urbach, B. Meissner, C. Nicolay, H. A. Kretzschmar, M. Knauth, and I. Zerr MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease: a study on inter-observer agreement Brain, September 1, 2005; 128(9): 2026 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nodera, A. Mori, Y. Izumi, T. Sakamoto, and R. Kaji Creutzfeldt-Jakob disease manifesting as posterior cortical dementia Neurology, July 26, 2005; 65(2): 330 - 330. [Full Text] [PDF]
|
|
|
|
|
|
G. S. Young, M. D. Geschwind, N. J. Fischbein, J. L. Martindale, R. G. Henry, S. Liu, Y. Lu, S. Wong, H. Liu, B. L. Miller, et al. Diffusion-Weighted and Fluid-Attenuated Inversion Recovery Imaging in Creutzfeldt-Jakob Disease: High Sensitivity and Specificity for Diagnosis AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1551 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hamaguchi, T. Kitamoto, T. Sato, H. Mizusawa, Y. Nakamura, M. Noguchi, Y. Furukawa, C. Ishida, I. Kuji, K. Mitani, et al. Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease Neurology, February 22, 2005; 64(4): 643 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 DWI Helps Detect CJD; MRI Helps Distinguish Prion Phenotypes Journal Watch Neurology, December 10, 2004; 2004(1210): 6 - 6. [Full Text]
|
|
|
|
|
|
M. Zeidler and A. Green Advances in diagnosing Creutzfeldt-Jakob disease with MRI and CSF 14-3-3 protein analysis Neurology, August 10, 2004; 63(3): 410 - 411. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
