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NEUROLOGY 2004;63:550-553
© 2004 American Academy of Neurology
Brief Communications

A limited role for DJ1 in Parkinson disease susceptibility

D. M. Maraganore, MD, K. Wilkes, BSc, T. G. Lesnick, MS, K. J. Strain, BS, M. de Andrade, PhD, W. A. Rocca, MD MPH, J. H. Bower, MD, J. E. Ahlskog, PhD MD, S. Lincoln, BSc and M. J. Farrer, PhD

From the Departments of Neurology (Drs. Maraganore, Rocca, Bower, and Ahlskog) and Health Sciences Research (Drs. de Andrade and Rocca, T.G. Lesnick and K.J. Strain), Mayo Clinic Rochester, MN, and Department of Neuroscience (Dr. Farrer, K.Wilkes and S. Lincoln), Mayo Clinic Jacksonville, FL.

Address correspondence and reprint requests to Dr. D.M. Maraganore, Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905; e-mail: dmaraganore{at}mayo.edu

An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. PD probands were compared with their unaffected siblings matched by gender and closest age at study (416 vs 416) and with unrelated control subjects (691 vs 190). None of the four haplotype tagging single-nucleotide polymorphisms (SNPs) was associated with PD overall, but SNP1 (position 4,345 bp) and SNP3 (position 16,491 bp) were associated with PD in women (p = 0.03 and p = 0.002).

Received December 23, 2003. Accepted in final form March 25, 2004.




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