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From the Departments of Infectious Diseases (Dr. McBride, M. Lane) and Neurology (Dr. Archer), Cairns Base Hospital, and School of Medicine, James Cook University, Queensland, Australia.
Address correspondence and reprint requests to Dr. John Archer, Senior Lecturer in Medicine, James Cook University, Clinical School, Cairns Base Hospital, The Esplanade, Cairns, Queensland 4870, Australia; e-mail: John.Archer{at}jcu.edu.au
The authors describe the clinical course of Cryptococcus neoformans variety gattii infection in a young immunocompetent man who had a late deterioration characterized by headaches, subarachnoid inflammation, hydrocephalus, and stroke that reproducibly responded to steroids. These findings, in combination with declining markers of CSF infection, are consistent with the late deterioration being caused by sterile arachnoiditis rather than ongoing infection.
Received August 8, 2003. Accepted in final form April 12, 2004.
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