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NEUROLOGY 2004;63:736-738
© 2004 American Academy of Neurology
Brief Communications

Activated platelets in transient global amnesia and TIA

Hisayuki Hirabayashi, MD PhD, Mie Shimizu, PhD, Saori Kohara and Yukito Shinohara, MD PhD

From the Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan.

Address correspondence and reprint requests to Dr. Hisayuki Hirabayashi, Department of Neurology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259-1193, Japan; e-mail: hhirabay{at}is.icc.u-tokai.ac.jp

To assess whether platelets are activated in transient global amnesia (TGA) and TIA, blood samples were analyzed by fluorescence-activated cytoscan using antibodies specific for platelet fibrinogen receptor (PAC1) and P-selectin (CD62P). Samples from TIA contained high levels of CD62P compared with age-matched control subjects, whereas those from TGA did not. The authors suggest that activated platelets are involved in brain ischemia, whereas ischemia appears not to be associated with most TGA.

Received December 4, 2003. Accepted in final form March 26, 2004.




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