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NEUROLOGY 2004;63:742-745
© 2004 American Academy of Neurology
Brief Communications

Regional reductions of gray matter volume in familial dyslexia

S. M. Brambati, BS, C. Termine, MD, M. Ruffino, BS, G. Stella, PhD, F. Fazio, MD, S. F. Cappa, MD and D. Perani, MD

From the Vita-Salute San Raffaele University (Drs. Cappa and Perani, S.M. Brambati and M. Ruffino), IBFM (Drs. Cappa, Perani, and Fazio), CNR, Segrate Milan, and University of Milano–Bicocca (Dr. Fazio), Milan, Child Neuropsychiatry Unit (Dr. Termine), University of Insubria, Varese, and Psychology Institute (Dr. Stella), University of Urbino, Italy.

Address correspondence and reprint requests to Dr. D. Perani, Vita-Salute H San Raffaele University, Via Olgettina 60, 20132 Milano, Italy; e-mail: daniela.perani{at}hsr.it

An in vivo anatomic study of gray matter volume was performed in a group of familial dyslexic individuals, using an optimized method of voxel-based morphometry. Focal abnormalities in gray matter volume were observed bilaterally in the planum temporale, inferior temporal cortex, and cerebellar nuclei, suggesting that the underlying anatomic abnormalities may be responsible for defective written language acquisition in these subjects.

Received October 31, 2003. Accepted in final form March 31, 2004.




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