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4 predicts dementia but not other psychiatric disorders after traumatic brain injury
From the Departments of Psychiatry (Drs. Koponen and Taiminen), Clinical Chemistry and Hematology (Dr. Kairisto), and Neurology (Drs. Portin, Isoniemi, and Tenovuo), Turku University Hospital, Finland; and the Department of Biostatistics (Dr. Hinkka), University of Turku, Finland.
Address correspondence and reprint requests to Dr. Salla Koponen, Department of Psychiatry, Turku University Hospital, PL 52, FIN-20521 Turku, Finland; e-mail: salla.koponen{at}utu.fi
The authors studied the association between APOE-
4 genotype and axis I and II psychiatric disorders an average of 30 years after traumatic brain injury. Sixty patients were dichotomized into subjects with and without APOE-
4 allele. Dementia and subclinical dementia were significantly more common with the presence of APOE-
4. The occurrence of other psychiatric disorders did not differ between patients with and without APOE-
4 allele.
Received October 1, 2003. Accepted in final form April 20, 2004.
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H. Isoniemi, T. Kurki, O. Tenovuo, V. Kairisto, and R. Portin Hippocampal volume, brain atrophy, and APOE genotype after traumatic brain injury. Neurology, September 12, 2006; 67(5): 756 - 760. [Abstract] [Full Text] [PDF] |
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