| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Epidemiology (Dr. Hernán), Harvard School of Public Health, Boston; Boston Collaborative Drug Surveillance Program (Drs. Susan S. Jick and Hershel Jick), Boston University, Lexington, MA; and Department of Neurology (Dr. Olek), College of Medicine, University of California, Irvine.
Address correspondence and reprint requests to Dr. Miguel Hernán, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115; e-mail: miguel_hernan{at}post.harvard.edu
Background: A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations.
Methods: The authors conducted a nested case-control study within the General Practice Research Database (GPRD) in the United Kingdom. The authors identified patients who had a first MS diagnosis recorded in the GPRD between January 1993 and December 2000. Cases were patients with a diagnosis of MS confirmed through examination of medical records, and with at least 3 years of continuous recording in the GPRD before their date of first symptoms (index date). Up to 10 controls per case were randomly selected, matched on age, sex, practice, and date of joining the practice. Information on receipt of immunizations was obtained from the computer records.
Results: The analyses include 163 cases of MS and 1,604 controls. The OR of MS for vaccination within 3 years before the index date compared to no vaccination was 3.1 (95% CI 1.5, 6.3). No increased risk of MS was associated with tetanus and influenza vaccinations.
Conclusions: These findings are consistent with the hypothesis that immunization with the recombinant hepatitis B vaccine is associated with an increased risk of MS, and challenge the idea that the relation between hepatitis B vaccination and risk of MS is well understood.
Received March 31, 2004. Accepted in final form May 8, 2004.
See also page 772
Related Articles
Neurology 2004 63: 766-767.
Neurology 2004 63: 772-773.
This article has been cited by other articles:
|
|
 |
|
  M. Verweij and A. Dawson Public Health Research Ethics: A Research Agenda Public Health Ethics, April 1, 2009; 2(1): 1 - 6. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Mikaeloff, G. Caridade, S. Suissa, and M. Tardieu Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood Neurology, March 10, 2009; 72(10): 873 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Ness and J. F. Bale Jr Hepatitis vaccines and pediatric multiple sclerosis: Does timing or type matter? Neurology, March 10, 2009; 72(10): 870 - 871. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Djeriri, H. Laurichesse, J. L. Merle, R. Charof, A. Abouyoub, L. Fontana, N. Benchemsi, E. Elharti, R. El Aouad, A. Chamoux, et al. Hepatitis B in Moroccan health care workers Occup. Med., September 1, 2008; 58(6): 419 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Houzen, M Niino, D Hata, F Nakano, S Kikuchi, T Fukazawa, and H Sasaki Increasing prevalence and incidence of multiple sclerosis in northern Japan Multiple Sclerosis, August 1, 2008; 14(7): 887 - 892. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Mikaeloff, G. Caridade, M. Rossier, S. Suissa, and M. Tardieu Hepatitis B Vaccination and the Risk of Childhood-Onset Multiple Sclerosis Arch Pediatr Adolesc Med, December 1, 2007; 161(12): 1176 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Mikaeloff, G. Caridade, S. Assi, M. Tardieu, S. Suissa, and on behalf of the KIDSEP study group of the French Hepatitis B vaccine and risk of relapse after a first childhood episode of CNS inflammatory demyelination Brain, April 1, 2007; 130(4): 1105 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Hernan, A. Alonso, and S. Hernandez-Diaz Tetanus vaccination and risk of multiple sclerosis: a systematic review. Neurology, July 25, 2006; 67(2): 212 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alonso, S. S. Jick, H. Jick, and M. A. Hernan Antibiotic Use and Risk of Multiple Sclerosis Am. J. Epidemiol., June 1, 2006; 163(11): 997 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Alonso, S. S. Jick, and M. A. Hernan Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosis Neurology, February 28, 2006; 66(4): 572 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Grytten, S. B. Glad, J. H. Aarseth, H. Nyland, R. Midgard, and K-M Myhr A 50-year follow-up of the incidence of multiple sclerosis in Hordaland County, Norway Neurology, January 24, 2006; 66(2): 182 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.H. Hawkes Are multiple sclerosis patients risk-takers? QJM, December 1, 2005; 98(12): 895 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alonso, S. S. Jick, M. J. Olek, A. Ascherio, H. Jick, and M. A. Hernan Recent Use of Oral Contraceptives and the Risk of Multiple Sclerosis Arch Neurol, September 1, 2005; 62(9): 1362 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. MacIntyre, H. Kelly, D. Jolley, H. Butzkueven, D. Salmon, N. Halsey, L. H. Moulton, F. DeStefano, E. S. Weintraub, R. T. Chen, et al. Recombinant hepatitis B vaccine and the risk of multiple sclerosis: A prospective study Neurology, April 12, 2005; 64(7): 1317 - 1317. [Full Text] [PDF]
|
|
|
|
 |
|
 Is Hepatitis B Vaccine Linked with Risk for MS? Journal Watch Neurology, November 29, 2004; 2004(1129): 6 - 6. [Full Text]
|
|
|
|
 |
|
 O. Dyer Study suggests hepatitis B vaccine increases risk of multiple sclerosis BMJ, September 25, 2004; 329(7468): 703. [Full Text]
|
|
|
|
|
|
R. T. Naismith and A. H. Cross Does the hepatitis B vaccine cause multiple sclerosis? Neurology, September 14, 2004; 63(5): 772 - 773. [Full Text] [PDF]
|
|
Read all Correspondence
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
