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NEUROLOGY 2004;63:897-900
© 2004 American Academy of Neurology
Brief Communications

Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy

Rachel Katz-Brull, PhD, Robert E. Lenkinski, PhD, Renaud A. Du Pasquier, MD and Igor J. Koralnik, MD

From the Departments of Radiology (Drs. Katz-Brull and Lenkinski) and Neurology (Drs. Du Pasquier and Koralnik), and Division of Viral Pathogenesis (Drs. Du Pasquier and Koralnik), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Dr. Igor J. Koralnik, Director, HIV/Neurology Center, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RE 213B, Boston, MA 02215; e-mail: ikoralni{at}bidmc.harvard.edu

MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.

Received February 3, 2004. Accepted in final form April 20, 2004.




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