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NEUROLOGY 2004;63:904-906
© 2004 American Academy of Neurology
Brief Communications

Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas

V. H.J.M. Triebels, MD, M. J.B. Taphoorn, MD, A. A. Brandes, MD, J. Menten, MD, M. Frenay, MD, A. Tosoni, MD, J. M. Kros, MD, E. Biemond-ter Stege, MD, R. H. Enting, MD, A. Allgeier, PhD, I. van Heuvel, RN and M. J. van den Bent, MD

From the Departments of Neuro-Oncology (Drs. Triebels, Biemond-ter Stege, Enting, and van den Bent, and I. van Heuvel) and Pathology (Dr. Kros), Erasmus MC, Dr. Daniel den Hoed Cancer Center, Rotterdam, the Netherlands; Canisius Wilhelmina Hospital (Dr. Triebels), Nijmegen, the Netherlands; University Medical Center Utrecht (Dr. Taphoorn), the Netherlands; Medical Oncology Department (Drs. Brandes and Tosoni), University Hospital Padova, Italy; Department of Radiotherapy-Oncology (Dr. Menten), University Hospital Gasthuisberg, Leuven, Belgium; Centre Antoine Lacassagne (Dr. Frenay), Nice, France; and EORTC DataCenter (Dr. Allgeier), Brussels, Belgium.

Address correspondence and reprint requests to Dr. M.J. van den Bent, Dept Neuro-Oncology, Daniel den Hoed Cancer Center/Erasmus University Hospital Rotterdam, PO Box 5201, 3008AE Rotterdam, the Netherlands; e-mail: m.vandenbent{at}erasmusmc.nl

The authors investigated the results of PCV chemotherapy within a cohort of 24 patients treated within the EORTC study 26971 on temozolomide chemotherapy in recurrent oligodendroglioma. The genotype of the tumors was assessed with fluorescent in situ hybridization with locus specific probes for the region 1p36. Four of the 24 patients responded (17%). Fifty percent of patients were still free from progression at 6 months and 21% were free from progression at 12 months. Although a clear relation existed between loss of 1p and response to temozolomide chemotherapy, this relation was absent in salvage PCV chemotherapy.

Received February 16, 2004. Accepted in final form May 11, 2004.

Presented in part at the 13th European Neurological Society meeting; Istanbul; June 14–18, 2003.

E.B.S. was the recipient of the unrestricted EORTC grant AZ/01/02 from Astra Zeneca.




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