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NEUROLOGY 2004;63:907-909
© 2004 American Academy of Neurology
Brief Communications

Thalamic deep brain stimulation activates the cerebellothalamocortical pathway

G. F. Molnar, MSc, A. Sailer, MD, C. A. Gunraj, MHSc, A. E. Lang, MD, FRCPC, A. M. Lozano, MD, PhD, FRCSC and R. Chen, MB, BChir, MSc, FRCPC

From the Divisions of Neurology (Drs. Sailer, Lang, and Chen, G.F. Molnar and C.A. Gunraj) and Neurosurgery (Dr. Lozano), Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada.

Address correspondence and reprint requests to Dr. Robert Chen, 5W445, 399 Bathurst Street, Toronto, Ontario, M5T 1S8, Canada; e-mail: Robert.chen{at}uhn.on.ca

To investigate the mechanism of action of deep brain stimulation (DBS), the authors studied the effects of thalamic DBS on the cerebellothalamocortical (CTC) pathway. With DBS turned off, excitability of the CTC pathway was reduced. Turning DBS on resulted in facilitation of the CTC pathway. Therefore, thalamic DBS appears to activate rather than inhibit the target area.

Received January 8, 2004. Accepted in final form April 20, 2004.




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