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APOE-dependent PET patterns of brain activation in Alzheimer disease

From the Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer’s Disease and the Aging Brain (Drs. Scarmeas, Hilton, Habeck, and Stern, A. Park and J. Flynn) and the Departments of Neurology (Drs. Scarmeas and Stern) and Pathology (Dr. Tycko), College of Physicians and Surgeons of Columbia University; New York, NY; and the Department of Psychiatry (Dr. Anderson), University of Maryland, Baltimore, MD.

Address correspondence and reprint requests to Dr. Nikolaos Scarmeas, Columbia Presbyterian Medical Center, 622 West 168th Street, PH 19th floor, New York, NY 10032; e-mail: ns257{at}columbia.edu

Using H₂¹⁵O PET, the authors imaged 13 patients with Alzheimer disease (AD) while performing a serial nonverbal recognition memory task. Patterns of brain activation differed as a function of APOE genotype: 4 carriers exhibited lower activation in the left lingual gyrus and higher activation in left cuneus, precuneus, parahippocampal, and right precentral gyrus. The APOE genotype seems to play a role in cerebral physiologic activity even after onset of clinical manifestations of AD.

Received October 19, 2003. Accepted in final form May 5, 2004.

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