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NEUROLOGY 2004;63:919-921
© 2004 American Academy of Neurology
Brief Communications

The prevalence of pain in multiple sclerosis

A multicenter cross-sectional study

C. Solaro, MD, G. Brichetto, MD, M. P. Amato, MD, E. Cocco, MD, B. Colombo, MD, G. D’Aleo, MD, C. Gasperini, MD, A. Ghezzi, MD, V. Martinelli, MD, C. Milanese, MD, F. Patti, MD, M. Trojano, MD, E. Verdun, MD, G. L. Mancardi, MD and the PaIMS Study Group*

From the Department of Neurology (Dr. Solaro), "P.A. Micone" Hospital, Genova; Departments of Neurosciences, Ophthalmology, and Genetics (Drs. Brichetto and Mancardi) and Centre of Excellence for Biomedical Research (Dr. Mancardi), University of Genova; Department of Neurology and Psychiatry (Dr. Amato), University of Firenze; Department of Neurosciences (Dr. Cocco), University of Cagliari; Department of Neurology (Drs. Colombo and Martinelli), S. Raffaele Hospital, Milan; Neurolesi Centre (Dr. D’Aleo), AUSL 5 Messina; Department of Neurosciences (Dr. Gasperini), S. Camillo Forlanini Hospital, Rome; MS Centre (Dr. Ghezzi), S. Antonio Abate Hospital, Gallarate; "C. Besta" Neurological Institute (Dr. Milanese), Milan; Department of Neurosciences (Dr. Patti), MS Centre University of Catania; Department of Neurological Sciences (Dr. Trojano), Bari; and Department of Neurology (Dr. Verdun), Torino, Italy.

Address correspondence and reprint requests to Dr. Claudio Solaro, Department of Neurology, "P.A. Micone" Hospital, Genova, Italy; e-mail: csolaro{at}libero.it

In a multicenter cross-sectional study, the authors assessed pain in patients with multiple sclerosis (MS) using a symptom-oriented approach. Out of 2,077 questionnaires, we used 1,672 for data analysis. Pain and frequencies included trigeminal neuralgia 2%, Lhermitte’s sign 9%, dysesthetic pain 18.1%, back pain 16.4%, and painful tonic spasms 11%. Comparison between different groups showed significant differences for age, Expanded Disability Status Scale, disease duration, and disease course, but not for sex. This study underlines the relevance of pain in the clinical history of MS.

Received December 12, 2003. Accepted in final form May 8, 2004.

*Members of the PaIMS Study Group are listed in the Appendix on page 921.




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