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NEUROLOGY 2004;63:930-932
© 2004 American Academy of Neurology
Brief Communications

Long-term effect of CPAP in the treatment of nocturnal stridor in multiple system atrophy

A. Iranzo, MD, J. Santamaria, MD, E. Tolosa, MD, I. Vilaseca, MD, F. Valldeoriola, MD, M. J. Martí, MD and E. Muñoz, MD

From the Neurology Service (Drs. Iranzo, Santamaria, Tolosa, Valldeoriola, Martí, and Muñoz), Hospital Clínic and Instisut d’Investigació Biomèdiques August Pi i Sunyer (IDIBAPS); and Otorhinolaryngology Service (Dr. Vilaseca), Hospital Clinic Universitari de Barcelona, Spain.

Address correspondence and reprint requests to Dr. Alex Iranzo, Neurology Service, Hospital Clinic de Barcelona, C/Villarroel 170, Barcelona 08036, Spain; e-mail: airanzo{at}clinic.ub.es

The authors found that continuous positive airway pressure (CPAP) eliminated video-polysomnographic documented stridor in 13 multiple system atrophy (MSA) subjects with vocal cord abnormalities. Long-term follow-up showed high CPAP tolerance, no recurrence of stridor, no major side effects, subjective improvement in sleep quality, and that median survival time was similar to a group of 26 MSA patients without stridor. This study shows that in MSA, CPAP is an effective noninvasive long-term therapy for nocturnal stridor.

Received March 11, 2004. Accepted in final form May 8, 2004.




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