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NEUROLOGY 2004;63:1084-1086
© 2004 American Academy of Neurology
Brief Communications

Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis

M. G. Marrosu, MD, C. Sardu, BS, E. Cocco, MD, G. Costa, BS, M. R. Murru, BS, C. Mancosu, BS, R. Murru, BS, M. Lai, MD and P. Contu, MD

From the Multiple Sclerosis Center (Drs. Marrosu, Cocco, and Lai, and G. Costa, M.R. Murru, C. Mancosu, and R. Murru), Department of Neuroscience, Department of Public Health (C. Sardu and Dr. Contui), University of Cagliari, Italy.

Address correspondence and reprint requests to Prof. Maria Giovanna Marrosu, Centro Sclerosi Multipla, Ospedale Binaghi, Via Is Guadazzonis, 2, 09126 Cagliari, Italy; e-mail: gmarrosu{at}unica.it

The authors analyzed the female: male (F:M) ratio according to the HLA-DRB1-DQB1 genotype in a cohort of multiple sclerosis (MS) patients from Sardinia, where the disease is associated with DR3 and DR4. In the whole cohort of 1,097 patients, F:M ratio was 2.24; however, it was 2.88 in DR3/DR3 and 2.52 in DR3/DRX (X#DR3 and DR4) individuals. Parental transmission of DR3 and DR4, assessed in a set of 565 case-parent triads, showed evidence of paternal inheritance of DR3 in affected women, thus explaining the excess of females in the DR3 category.

Received February 19, 2004. Accepted in final form May 11, 2004.




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B. Herrera, M. Cader, D. Dyment, J. Bell, G. DeLuca, C. Willer, M. Lincoln, S. Ramagopalan, M. Chao, S-M. Orton, et al.
Multiple sclerosis susceptibility and the X chromosome
Multiple Sclerosis, August 1, 2007; 13(7): 856 - 864.
[Abstract] [PDF]


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