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Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy

From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.

Address correspondence and reprint requests to Dr. Fritz Zimprich, Universitaetsklinik fur Neurologie, Allgemeines Krankenhaus der Stadt Wien, Waehringer Guertel 18–20, A-1090 Vienna, Austria; e-mail: friedrich.zimprich{at}meduniwien.ac.at

The multidrug transporter P-glycoprotein is suspected of contributing to pharmacoresistance in temporal lobe epilepsy (TLE). To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance. They identified a common haplotype that when present in the homozygous state significantly increased the risk for pharmacoresistance.

Received December 5, 2003. Accepted in final form July 19, 2004.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 28 issue to find the title link for this article.

See also pages 955 and 1090

*F. Z. and R.S.-P. contributed equally.

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