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From the Departments of Neurology (Drs. Kaufmann and Nahm) and Pathology (Neuropathology) (Drs. Purohit and Wolfe), Mount Sinai School of Medicine, New York, NY.
Address correspondence and reprint requests to Dr. Horacio Kaufmann, Mount Sinai School of Medicine, Box 1052, New York, NY 10029; e-mail: Horacio.Kaufmann{at}mssm.edu
The authors report the clinical and postmortem neuropathologic findings of two patients, one with Parkinson disease (PD) and one with dementia with Lewy bodies (DLB), both of whom initially sought treatment for isolated autonomic failure. These cases suggest that neurodegeneration in PD and DLB may begin outside the CNS in autonomic postganglionic neurons, a finding with potential diagnostic and therapeutic implications.
Received December 22, 2003. Accepted in final form May 19, 2004.
See also page 953
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