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NEUROLOGY 2004;63:1105-1107
© 2004 American Academy of Neurology
Brief Communications

ApoE {epsilon}4 allele is associated with incidental hallucinations and delusions in patients with AD

J. B. Chang, MD, P. N. Wang, MD, W. T. Chen, MD, C. Y. Liu, MD, C. J. Hong, MD, K. N. Lin, PhD, T. Y. Liu, PhD, C. W. Chi, PhD and H. C. Liu, MD

From the Departments of Neurology (Drs. Chang, Wang, Chen, Lin, and H.C. Liu), Psychiatry (Dr. Hong), and Institute of Pharmacology (Drs. T.Y. Liu and Chi), National Yang-Ming University School of Medicine; the Neurological Institute (Drs. Chang, Wang, Lin, and H.C. Liu), Departments of Psychiatry (Dr. Hong) and Medical Research and Education (Drs. Chi and T.Y. Liu), Taipei Veterans General Hospital; Department of Internal Medicine (Dr. Chen), Chutung Veterans Hospital; Department of Psychiatry (Dr. C.Y. Liu), Chang Gung Memorial Hospital, Lin-Kou; and Department of Psychology (Dr. Lin), Fu Jen Catholic University, Taipei County, Taiwan.

Address correspondence and reprint requests to Dr. Hsiu-Chih Liu, The Neurologic Institute, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan; e-mail: hcliu{at}vghtpe.gov.tw

Of 135 patients with Alzheimer disease (AD), 56 without psychiatric symptoms at the first visit were followed for a mean period of 51.9 ± 10.3 months to identify incident psychiatric symptoms. The hazard ratios of ApoE {epsilon}4 allele in developing psychiatric symptoms were calculated by Cox regression hazard analyses. The presence of the ApoE {epsilon}4 allele carried a 19.0-fold risk for developing hallucinations and a 3.4-fold risk for delusions.

Received February 16, 2004. Accepted in final form May 14, 2004.




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The effect of the apolipoprotein E gene polymorphisms and haplotypes on behavioural and psychological symptoms in probable Alzheimer's disease
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[Abstract] [Full Text] [PDF]


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