HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Binkofski, F. Articles by Seitz, R. J. Search for Related Content PubMed PubMed Citation Articles by Binkofski, F. Articles by Seitz, R. J. Related Collections fMRI All Cerebrovascular disease/Stroke Plasticity Infarction

Modulation of the BOLD-response in early recovery from sensorimotor stroke

From the Department of Neurology (Dr. Binkofski), University Hospital Schleswig-Holstein, Campus Lübeck, Germany; Neuroimage Nord (Dr. Binkofski), University Hospital Eppendorf, Hamburg, Germany; and Department of Neurology (Dr. Seitz), University Hospital Düsseldorf, Germany.

Address correspondence and reprint requests to Dr. Ferdinand Binkofski, Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23539 Lübeck, Germany; e-mail: binkofski.f{at}neuro.mu-luebeck.de

Background: The BOLD signal in functional MRI (fMRI) is closely related to neural activity.

Objective: To investigate if this relationship is disrupted after ischemic stroke.

Methods: BOLD activity during tactile exploration of objects was measured with fMRI at 1 week (subacute), 2 to 4 weeks (early chronic), and after 1 month (chronic) after the first completed brain infarction affecting the sensorimotor cortex in eight patients. Functional integrity of the motor cortical output system was assessed with transcranial magnetic stimulation (TMS).

Results: Early after infarction the BOLD-response occurred in the adjacent cortical vicinity related to finger movements of the affected hand. However, during the early chronic stage there was a transient lack of this activation despite clinical improvement of hand function and preserved motor evoked potentials. The BOLD activity reappeared after further improvement in the chronic stage.

Conclusions: Our findings suggest a transient hemodynamic-electrical decoupling in the post-ischemic cerebral cortex during the early phase of spontaneous clinical recovery.

Received December 29, 2003. Accepted in final form May 25, 2004.

This article has been cited by other articles:

				Y. Murata, K. Sakatani, T. Hoshino, N. Fujiwara, T. Kano, S. Nakamura, and Y. Katayama Effects of Cerebral Ischemia on Evoked Cerebral Blood Oxygenation Responses and BOLD Contrast Functional MRI in Stroke Patients Stroke, October 1, 2006; 37(10): 2514 - 2520. [Abstract] [Full Text] [PDF]

				P. Weller, H.-J. Wittsack, M. Siebler, V. Homberg, and R. J. Seitz Motor Recovery as Assessed with Isometric Finger Movements and Perfusion Magnetic Resonance Imaging after Acute Ischemic Stroke Neurorehabil Neural Repair, September 1, 2006; 20(3): 390 - 397. [Abstract] [PDF]

				S. C. Cramer, R. Shah, J. Juranek, K. R. Crafton, and V. Le Activity in the Peri-Infarct Rim in Relation to Recovery From Stroke Stroke, January 1, 2006; 37(1): 111 - 115. [Abstract] [Full Text] [PDF]

				B. H. Dobkin Rehabilitation after Stroke N. Engl. J. Med., April 21, 2005; 352(16): 1677 - 1684. [Full Text] [PDF]

				J.-C. Baron and S. Warach Imaging Stroke, February 1, 2005; 36(2): 196 - 199. [Full Text] [PDF]