NEUROLOGY 2004;63:1240-1244
© 2004 American Academy of Neurology
Incidence of parkinsonism and Parkinson disease in a general population
The Rotterdam Study
L. M.L. de Lau, MD,
P. C.L.M. Giesbergen, MD,
M. C. de Rijk, MD, PhD,
A. Hofman, MD, PhD,
P. J. Koudstaal, MD, PhD and
M. M.B. Breteler, MD, PhD
From the Departments of Epidemiology & Biostatistics (Drs. de Lau, Giesbergen, Hofman, and Breteler) and Neurology (Drs. de Lau, de Rijk, and Koudstaal), Erasmus Medical Center, Rotterdam, The Netherlands.
Address correspondence and reprint requests to Dr. M.M.B. Breteler, Department of Epidemiology and Biostatistics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands; e-mail: m.breteler{at}erasmusmc.nl
Objective: To investigate the incidence of parkinsonism and Parkinson disease (PD) in the general population using in-person screening along with clinical data.
Methods: In the Rotterdam study, a prospective population-based cohort study of people aged  55 years, the authors assessed age- and sex-specific incidence rates of parkinsonism and PD among 6,839 participants who were free of parkinsonism at baseline. Case finding involved in-person screening at baseline and two follow-up visits, and additional information was obtained through continuous monitoring of the cohort by computer linkage to general practitioners’ and pharmacy records.
Results: After a mean follow-up period of 5.8 years, 132 subjects with incident parkinsonism were identified, of whom 67 (51%) had PD. The incidence of parkinsonism and PD increased with age, with incidence rates for PD increasing from 0.3 per 1000 person-years in subjects aged 55 to 65 years, to 4.4 per 1000 person-years for those aged 85 years. The overall age-adjusted incidence rate of any parkinsonism was not different in men and women, but men seem to have a higher risk for PD (male-to-female ratio, 1.54; 95% CI, 0.95 to 2.51).
Conclusion: Incidence rates for parkinsonism and Parkinson disease were higher than those reported by most previous studies, possibly because of the authors’ intensive case-finding methods involving in-person screening.
Received February 20, 2004.
Accepted in final form May 26, 2004.
Related Article
-
October 12 Highlights
Neurology 2004 63: 1146-1147.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
G Alves, B Muller, K Herlofson, I HogenEsch, W Telstad, D Aarsland, O-B Tysnes, J P Larsen, and for the Norwegian ParkWest study group
Incidence of Parkinson's disease in Norway: the Norwegian ParkWest study
J. Neurol. Neurosurg. Psychiatry,
August 1, 2009;
80(8):
851 - 857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Driver, G. Logroscino, J. M. Gaziano, and T. Kurth
Incidence and remaining lifetime risk of Parkinson disease in advanced age
Neurology,
February 3, 2009;
72(5):
432 - 438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. H. Lee, S. H. Yeo, S. W. Yong, and Y. J. Kim
Odour identification test and its relation to cardiac 123I-metaiodobenzylguanidine in patients with drug induced parkinsonism
J. Neurol. Neurosurg. Psychiatry,
November 1, 2007;
78(11):
1250 - 1252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K S M Taylor, J A Cook, and C E Counsell
Heterogeneity in male to female risk for Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
August 1, 2007;
78(8):
905 - 906.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A Haaxma, B. R Bloem, G. F Borm, W. J G Oyen, K. L Leenders, S. Eshuis, J. Booij, D. E Dluzen, and M. W I M Horstink
Gender differences in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
August 1, 2007;
78(8):
819 - 824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Kado, M.-H. Huang, C. B. Nguyen, E. Barrett-Connor, and G. A. Greendale
Hyperkyphotic Posture and Risk of Injurious Falls in Older Persons: The Rancho Bernardo Study
J Gerontol A Biol Sci Med Sci,
June 1, 2007;
62(6):
652 - 657.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Hirtz, D. J. Thurman, K. Gwinn-Hardy, M. Mohamed, A. R. Chaudhuri, and R. Zalutsky
How common are the "common" neurologic disorders?
Neurology,
January 30, 2007;
68(5):
326 - 337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. L. de Lau, P. J. Koudstaal, A. Hofman, and M. M. B. Breteler
Serum Cholesterol Levels and the Risk of Parkinson's Disease
Am. J. Epidemiol.,
November 15, 2006;
164(10):
998 - 1002.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.M.L. de Lau, P. J. Koudstaal, J. C.M. Witteman, A. Hofman, and M. M.B. Breteler
Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease.
Neurology,
July 25, 2006;
67(2):
315 - 318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P H Lee, J S Kim, D H Shin, S-N Yoon, and K Huh
Cardiac 123I-MIBG scintigraphy in patients with drug induced parkinsonism
J. Neurol. Neurosurg. Psychiatry,
March 1, 2006;
77(3):
372 - 374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. L. de Lau, P. J. Koudstaal, A. Hofman, and M. M. B. Breteler
Subjective Complaints Precede Parkinson Disease: The Rotterdam Study
Arch Neurol,
March 1, 2006;
63(3):
362 - 365.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. L. de Lau, C. M. A. Schipper, A. Hofman, P. J. Koudstaal, and M. M. B. Breteler
Prognosis of Parkinson Disease: Risk of Dementia and Mortality: The Rotterdam Study
Arch Neurol,
August 1, 2005;
62(8):
1265 - 1269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.M.L. de Lau, M. Bornebroek, J. C.M. Witteman, A. Hofman, P. J. Koudstaal, and M. M.B. Breteler
Dietary fatty acids and the risk of Parkinson disease: The Rotterdam Study
Neurology,
June 28, 2005;
64(12):
2040 - 2045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
