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NEUROLOGY 2004;63:1286-1288
© 2004 American Academy of Neurology
Expedited Brief Communication

A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache

I. Rainero, MD, PhD, S. Gallone, MD, W. Valfrè, MD, M. Ferrero, MD, G. Angilella, MD, C. Rivoiro, MD, E. Rubino, MD, P. De Martino, MD, L. Savi, MD, M. Ferrone, MD and L. Pinessi, MD

From the Neurology III Headache Center, Department of Neuroscience (Drs. Rainero, Valfrè, Ferrero, Rivoiro, Rubino, De Martino, Savi, and Pinessi), and SCDU Medical Genetics (Drs. Gallone, Angilella, and Ferrone), University of Turin, Italy.

Address correspondence and reprint requests to Dr. Innocenzo Rainero, Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15-10126 Turin, Italy; e-mail: irainero{at}molinette.piemonte.it

Abstract

Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls. Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.

Received June 21, 2004. Accepted in final form August 4, 2004.

Footnotes

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the October 12 issue to find the title link for this article.


Related articles in Neurology:

October 12 Highlights

Neurology 2004 63: 1146-1147. [Full Text]  



This article has been cited by other articles:


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L. Baumber, C. Sjostrand, M. Leone, H. Harty, G. Bussone, J. Hillert, R. C. Trembath, and M. B. Russell
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort
Neurology, June 27, 2006; 66(12): 1888 - 1893.
[Abstract] [Full Text] [PDF]


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