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 Volume 63, Number 7, October 12, 2004
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NEUROLOGY 2004;63:1289-1292
© 2004 American Academy of Neurology
Brief Communications

Bilateral volume reduction of the superior temporal areas in Landau–Kleffner syndrome

M. Takeoka, MD, J. J. Riviello, Jr., MD, F. H. Duffy, MD, F. Kim, MD, D. N. Kennedy, PhD, N. Makris, MD, V. S. Caviness, Jr., MD, DPhil and G. L. Holmes, MD

From the Departments of Neurology (Drs. Takeoka, Riviello, Duffy, and Holmes) and Radiology (Dr. Kim), Children’s Hospital Boston, and Departments of Neurology (Drs. Drs. Takeoka, Makris, and Caviness) and Radiology (Dr. Kennedy), Massachusetts General Hospital, and Harvard Medical School (Drs. Takeoka, Riviello, Duffy, Kim, Kennedy, Makris, Caviness, and Holmes), Boston, MA; Department of Medical Imaging (Dr. Kim), Children’s Memorial Hospital, Northwestern University Medical School, Chicago, IL; and Department of Neurology (Dr. Holmes), Dartmouth Medical School, Hanover, NH.

Address correspondence and reprint requests to Dr. M. Takeoka, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children’s Hospital, 300 Longwood Ave., Hunnewell 2, Boston, MA 02115; e-mail: maxtakeoka{at}aol.com

No specific anatomic abnormalities have been detected in typical Landau–Kleffner syndrome (LKS), an acquired epileptic aphasia with language regression in children. In four children with typical LKS without obvious anatomic abnormalities, the authors performed MRI volumetric analysis of various neocortical regions and subcortical substructures. Volume reduction was detected in bilateral superior temporal areas (26 to 51%), specifically in planum temporale (25 to 63%) and superior temporal gyrus (25 to 57%), where receptive language is localized.

Received November 12, 2003. Accepted in final form May 14, 2004.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the October 12 issue to find the title link for this article.

See also page 1152

Presented in part at the annual meeting of the American Epilepsy Society, Los Angeles, CA, December 1, 2000 (MRI volumetric analysis and correlating quantitative EEG in Landau–Kleffner syndrome; abstract reprinted by permission of the journal Epilepsia).


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