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NEUROLOGY 2004;63:1299-1301
© 2004 American Academy of Neurology
Brief Communications

Polyomaviruses and primary central nervous system lymphomas

Jacinta M. Murray, BS and Susan Morgello, MD

From the Department of Pathology, Division of Neuropathology, Mount Sinai School of Medicine, New York, NY.

Address correspondence and reprint requests to Jacinta Murray, Department of Pathology, Box 1143, Mount Sinai School of Medicine, New York, NY 11377; e-mail: jacinta.murray{at}mssm.edu

The authors investigated the potential association of human primary CNS non-Hodgkin lymphoma (PCNSL) with polyomavirus in HIV-1 infected and uninfected individuals. Immunohistochemical analysis of CNS biopsies from 19 HIV-negative and 17 HIV-positive patients and PCR analysis of 12 HIV-negative and 14 HIV-positive patients revealed that the lymphomas were uniformly negative for polyomaviruses. The authors conclude that polyomaviruses are unlikely to be related to the pathogenesis of most PCNSL.

Received August 1, 2003. Accepted in final form May 20, 2004.




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