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NEUROLOGY 2004;63:1320-1322
© 2004 American Academy of Neurology
Brief Communications

Changes in cognitive function after neuronal cell transplantation for basal ganglia stroke

C. S. Stilley, PhD, C. M. Ryan, PhD, D. Kondziolka, MD, MSc, FRCSC, A. Bender, PhD, S. DeCesare, RN and L. Wechsler, MD

From the Neurotransplantation Research Program and School of Nursing (Drs. Stilley, Ryan, and Bender) and Departments of Psychiatry (Drs. Stilley and Ryan), Neurological Surgery (Dr. Kondziiolka), and Neurology (Dr. Wechsler, S. DeCesare), University of Pittsburgh, PA.

Address correspondence and reprint requests to Dr. C.S. Stilley, 3500 Victoria St., Rm. 360R, Pittsburgh, PA 15261; e-mail: css100{at}pitt.edu

Reported is the change in cognitive function after neuronal cell transplantation as a treatment for basal ganglia stroke. Nine subjects (two controls, seven transplants), all over 2 years post stroke, completed a comprehensive neuropsychological test battery prior to and 6 months after treatment. Four transplanted subjects who had strokes in the nondominant hemisphere showed marked improvement on the Rey Complex Figure, a test of visuospatial/constructional ability and nonverbal memory.



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  		Figure. Rey Figure copy: before and 6 months after neuronal cell transplantation.

 

Received January 21, 2004. Accepted in final form May 28, 2004.




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