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NEUROLOGY 2004;63:1452-1456
© 2004 American Academy of Neurology

A fetal circle of Willis is associated with a decreased deep white matter lesion load

J. van der Grond, PhD, A. F. van Raamt, MD, Y. van der Graaf, MD PhD, W. P.T.M. Mali, MD PhD and R. H.C. Bisschops, MD PhD

From the Department of Radiology (Drs. Van der Grond, Mali, and Bisschops) and Julius Center for Health Sciences and Primary Care, NWO and the SMART study group (Drs. Van Raamt and van der Graaf), University Medical Center Utrecht, the Netherlands.

Address correspondence and reprint requests to Dr. J. van der Grond, Department of Radiology, E01.132, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands; e-mail: j.vandergrond{at}azu.nl

Objective: To investigate the relationship between morphologic differences in the circle of Willis and the presence and location of white matter lesions (WMLs).

Methods: Two hundred forty-three consecutive patients with clinical manifestations of atherosclerotic disease underwent MRI of the brain and MR angiography of the circle of Willis.

Results: Subjects with a fetal configuration of the circle of Willis demonstrated a decreased load of small (p < 0.01) and medium (p < 0.01) deep WMLs compared with subjects with a nonfetal configuration of the posterior part of the circle of Willis.

Conclusion: A fetal configuration of the posterior part of the circle of Willis may be an important protecting determinant in the etiology of white matter lesions.

Received March 10, 2004. Accepted in final form June 11, 2004.


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Correspondence:

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A fetal circle of Willis is associated with a decreased deep white matter lesion load
Ken Ikeda, et al.
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