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NEUROLOGY 2004;63:1482-1485
© 2004 American Academy of Neurology
Brief Communications

PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations

Y. Hatano, MD, K. Sato, MD PhD, B. Elibol, MD PhD, H. Yoshino, BS, Y. Yamamura, MD, V. Bonifati, MD PhD, H. Shinotoh, MD, M. Asahina, MD, S. Kobayashi, MD, A. R. Ng, MD, R. L. Rosales, MD PhD, S. Hassin-Baer, MD, Y. Shinar, PhD, C. S. Lu, MD, H. C. Chang, BS, Y. H. Wu-Chou, PhD, F. B. Ataç, PhD, T. Kobayashi, MD, T. Toda, MD PhD, Y. Mizuno, MD and N. Hattori, MD PhD

From the Department of Neurology (Drs. Hatano, Sato, T. Kobayashi, Mizuno, and Hattori, and H. Yoshino), Juntendo University School of Medicine, Tokyo, Japan; Department of Neurology (Dr. Elibol), Institute of Neurological Sciences and Psychiatry, Hacettepe University School of Medicine, Ankara; Institute of Health Science (Dr. Yamamura), Hiroshima University School of Medicine, Japan; Department of Clinical Genetics (Dr. Bonifati), Erasmus MC Rotterdam, The Netherlands; Department of Neurological Sciences (Dr. Bonifati), La Sapienza University, Rome, Italy; Department of Neurology (Dr. Shinotoh), Asahi Hospital for Neurological Diseases, Matsudo, Japan; Department of Neurology (Dr. Asahina), Chiba University Graduate School of Medicine, Japan; Department of Neurology (Dr. S. Kobayashi), Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan; the Third Department of Internal Medicine (Dr. Ng), Kagoshima University School of Medicine, Japan; Department of Neurology and Psychiatry (Dr. Rosales), University of Santo Tomas Faculty of Medicine and Surgery, Manila, Philippines; Parkinson’s Disease and Movement Disorders Clinic, Department of Neurology (Drs. Hassin-Baer and Shinar), Chaim Sheba Medical Center, Israel; Movement Disorder Unit, First Department of Neurology (Dr. Lu and H.C. Chang), and Human Molecular Genetics Laboratory (Dr. Wu-Chou), Chang Gung Memorial Hospital, Taipei, Taiwan; Department of Molecular Biology (Dr. Ataç), Baskent University School of Medicine, Ankara, Turkey; and Division of Functional Genomics (Dr. Toda), Osaka University Graduate School of Medicine, Suita, Japan; CREST, Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguchi, Saitama, Japan (Drs. Toda and Hattori).

Address correspondence and reprint requests to Dr. Nobutaka Hattori, Department of Neurology, Juntendo University School of Medicine, 2–1–1 Hongo, Bunkyo, Tokyo 113–0033, Japan; e-mail: nhattori{at}med.juntendo.ac.jp

The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.

Received February 11, 2004. Accepted in final form April 19, 2004.

See also pages 1350 and 1486


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