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Rapid infusion with valproate sodium is well tolerated in patients with epilepsy

From the Department of Neurology and Pediatrics (Dr. Wheless), University of Texas Health Science Center, Houston; Department of Neurology and Pediatrics (Drs. Pellock and Morton), Medical College of Virginia, Virginia Commonwealth University, Richmond, VA; Department of Neurology (Dr. Vazquez), New York University Medical Center, NY; Department of Neurological Sciences (Dr. Kanner), Rush University Medical Center, Chicago, IL; Department of Neurology (Dr. Ramsay), University of Miami, FL.

Address correspondence and reprint requests to Dr. John M. Pellock, Department of Neurology, Medical College of Virginia, 307 College Street, Richmond, VA 23219; e-mail: jpellock{at}hsc.vcu.edu

Many IV antiepileptic drugs administered in emergency situations to patients with prolonged seizures have serious adverse effects. For this reason, the authors conducted a multicenter, open-label, prospective, dose-escalation study of IV valproate sodium administered to patients with epilepsy at rates of infusion of up to 6 mg/kg/minute and doses of up to 30 mg/kg. Valproate sodium had no clinically significant negative effects on blood pressure and pulse rate and caused only mild-to-moderate, reversible adverse events.

Received December 17, 2003. Accepted in final form June 10, 2004.

J.W.W. has received research support and honoraria from Abbott Laboratories. J.M.P. has received research support and honoraria from and has served as a consultant and on the speaker’s bureaus for Abbott Laboratories. R.E.R. has received research support from and has served as a consultant for Abbott Laboratories.

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