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NEUROLOGY 2004;63:1513-1515
© 2004 American Academy of Neurology
Brief Communications

In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients

R. Lodi, MD, C. Tonon, MD, L. Vignatelli, MD, S. Iotti, PhD, P. Montagna, MD, B. Barbiroli, MD and G. Plazzi, MD

From the Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci" (Drs. Lodi, Tonon, Iotti, and Barbiroli) and Dipartimento di Scienze Neurologiche (Drs. Vignatelli, Montagna, and Plazzi), Universita’ di Bologna, Italy.

Address correspondence and reprint requests to Dr. Raffaele Lodi, Dipartimento di Medicina Clinica, e Biotecnologia Applicata "D. Campanacci," Universita’ di Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy; e-mail: raffaele.lodi{at}unibo.it

A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p < 0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.

Received March 29, 2004. Accepted in final form May 28, 2004.




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