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From the Department of Neurology (Dr. Roth), University of North Carolina, Chapel Hill, NC; Brain Rehabilitation Research Center (Drs. Nadeau and Triggs), Rehabilitation Outcomes Research Center (Dr. Nadeau), and the Geriatric Research, Education and Clinical Center (Dr. Nadeau), Malcolm Randall Department of Veterans Affairs Medical Center, Gainesville, FL; and the Department of Neurology (Drs. Nadeau and Triggs), University of Florida College of Medicine, Gainesville, FL.
Address correspondence and reprint requests to Dr. Stephen E. Nadeau, GRECC (182), Malcolm Randall DVA Medical Center, 1601 SW Archer Road, Gainesville, FL; e-mail: snadeau{at}ufl.edu
Repetitive transcranial magnetic stimulation (rTMS) may temporarily accelerate knowledge acquisition by neural networks, possibly by promoting rapid Hebbian learning. The authors tested this hypothesis in 20 normal subjects by comparing the impact of 25 minutes of high-frequency left dorsolateral prefrontal rTMS with that of sham rTMS on subsequent knowledge acquisition in several procedural and declarative memory domains. No significant group effects, positive or negative, were noted for any memory acquisition test, but prefrontal rTMS did reduce motor evoked potential threshold.
Received January 30, 2004. Accepted in final form June 14, 2004.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the October 26 issue to find the title link for this article.
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