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NEUROLOGY 2004;63:S12-S16
© 2004 American Academy of Neurology

Neurology supplements are not peer-reviewed. Information contained in Neurology supplements represent the opinions of the authors and are not endorsed by nor do they reflect the views of the American Academy of Neurology, Editor-in-Chief, or Associate Editors of Neurology.

Akathisia, restless legs and periodic limb movements in sleep in Parkinson’s disease

Werner Poewe, MD and Birgit Högl, MD

From the Department of Neurology, University of Innsbruck, Innsbruck, Austria.

Address correspondence and reprint requests to Dr. W. Poewe, Anichstrasse 35, A-6020, Innsbruck, Austria; e-mail: werner.poewe{at}uibk.ac.at

Restless legs syndrome (RLS) symptoms are often reported in Parkinson’s disease (PD), but prevalence studies of RLS in PD are few and the results are inconsistent. In addition, clinical overlapping between RLS, "wearing-off"-related lower limb discomfort and restlessness, and akathisia complicate the clinical assessments of true RLS in PD. Underlying pathophysiology potentially shared by RLS and PD is mainly suggested by similarities in treatment response. Functional imaging studies in RLS are still inconclusive, although some authors have found subtle deficits in nigrostriatal terminal function. Long-term prospective studies of RLS cohorts will clarify whether or not RLS is associated with an increased risk for development of PD.




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