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Different progression rates for deep white matter hyperintensities in elderly men and women

From the Department of Radiology (Dr. van Buchem, D.M.J. van den Heuvel), Division of Image Processing (Dr. Admiraal-Behloul, H. Olofsen), Department of Gerontology and Geriatrics (Drs. ten Dam, Blauw, Westendorp, and de Craen), General Internal Medicine Section, and Department of Neurology (Dr. Bollen), Leiden University Medical Center, the Netherlands; and Robertson Centre for Biostatistics (H.M. Murray), University of Glasgow, UK.

Address correspondence and reprint requests to D.M.J. van den Heuvel, Department of Radiology C2-S, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; e-mail: D.M.J.van_den_Heuvel{at}lumc.nl

The authors investigated the progression of white matter hyperintensities (WMHs) in a large population of elderly men and women. After 3 years of follow-up, women had accumulated approximately twice as much deep WMH (DWMH) as men. The progression of periventricular WMH was the same for men and women. Gender differences may affect the pathogenesis of DWMH, which in turn may result in different clinical consequences in women.

Received April 23, 2004. Accepted in final form June 15, 2004.

*See the Appendix on page 1701 for a list of Group members.

Drs. Blauw, van Buchem, Bollen, de Craen, and Westendorp received research support and travel grants from Bristol-Myers Squibb and other companies making competing products.

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