NEUROLOGY 2004;63:1705-1707
© 2004 American Academy of Neurology
Brief Communications
Impact of antioxidants, zinc, and copper on cognition in the elderly
A randomized, controlled trial*
Age-Related Eye Disease Study Research Group
Writing Team: Kristine Yaffe, MD, Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, and San Francisco VA Medical Center, CA; and Traci E. Clemons, PhD, Wendy L. McBee, MA, and Anne S. Lindblad, PhD, The EMMES Corporation, Rockville, MD.
Address correspondence and reprint requests to AREDS Coordinating Center, The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville, MD 20850–1707; e-mail: aredspub{at}emmes.com
Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; beta carotene, 15 mg), zinc and copper (zinc, 80 mg; cupric oxide, 2 mg), antioxidants plus zinc and copper, or placebo. A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment. Treatment groups did not differ on any of the six cognitive tests (p > 0.05 for all). These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults.
Received January 28, 2004.
Accepted in final form June 28, 2004.
Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 9 issue to find the title link for this article.
*AREDS Report No. 12.
A complete list of the members of the Age-Related Eye Disease Study (AREDS) Research Group is available on the Neurology Web site at www.neurology.org (Appendix E-1).
The Writing Team for this report and the AREDS investigators have no commercial or proprietary interest in the supplements used in this study.
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