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NEUROLOGY 2004;63:1708-1710
© 2004 American Academy of Neurology
Brief Communications

Cervical artery dissection

An atypical presentation with Ehlers–Danlos-like collagen pathology?

D. Ulbricht, MD, N. J. Diederich, MD, T. Hermanns-Lê, MD, R. J. Metz, MD, F. Macian, MD and G. E. Piérard, MD

From the Department de Neurologie (Drs. Ulbricht, Diederich, Metz, and Macian), Centre Hospitalier de Luxembourg, Luxembourg; and Service de Dermatopathologie (Drs. Hermanns-Lê and Piérard), University Hospital of Liège, Belgium.

Address correspondence and reprint requests to Dr. Dirk Ulbricht, 23-25 rue de l’Alzette, Esch-sur-Alzette, L-4011, Luxembourg; e-mail: ulbricht{at}macnews.de

The authors took skin biopsies of the macroscopically normal skin of seven consecutive patients with spontaneous cervical artery dissection (SCAD). Histologically, alterations of the collagen and elastic fiber networks were found in six patients. In five, the histologic, immunohistochemical, and ultrastructural changes were similar to those usually found in Ehlers–Danlos syndrome (EDS). This suggests that SCAD is frequently associated with the dermal alterations seen in EDS.

Received February 5, 2003. Accepted in final form June 21, 2004.




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