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NEUROLOGY 2004;63:1722-1724
© 2004 American Academy of Neurology
Brief Communications

Hypertrophic pachymeningitis as an initial and cardinal manifestation of microscopic polyangiitis

Yutaka Furukawa, MD, Yasuko Matsumoto, MD and Masahito Yamada, MD, PhD

From Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Japan.

Address correspondence and reprint requests to Dr. Yutaka Furukawa, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takara-machi, Kanazawa, Ishikawa 920-8640, Japan; e-mail: furukawa{at}med.kanazawa-u.ac.jp

The authors describe a 68-year-old man who developed hypertrophic pachymeningitis as an initial and cardinal manifestation of microscopic polyangiitis. The patient had a high titer of antineutrophil cytoplasmic antibody for myeloperoxidase. Biopsies revealed necrotizing glomerulonephritis in the kidney, small vessel vasculitis in the sural nerve, and infiltration of plasma cells and eosinophils in the thickened dura mater.

Received May 8, 2004. Accepted in final form June 23, 2004.




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