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NEUROLOGY 2004;63:1734-1736
© 2004 American Academy of Neurology
Brief Communications

Autoimmune etiology of complex regional pain syndrome (M. Sudeck)

F. Blaes, MD, K. Schmitz, M. Tschernatsch, MD, M. Kaps, MD, I. Krasenbrink, MD, G. Hempelmann, MD and M. E. Bräu, MD

From the Departments of Neurology (F. Blaes, K. Schmitz, M. Tschernatsch, M. Kaps, and I. Krasenbrink) and Anesthesiology (G. Hempelmann and M.E. Bräu), Justus-Liebig-University, Giessen, Germany.

Address correspondence and reprint requests to Dr. F. Blaes, Department of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany; e-mail: franz.blaes{at}neuro.med.uni-giessen.de

Sera of 12 patients with complex regional pain syndrome (CRPS) were tested for the occurrence of autoantibodies against nervous system structures. Immunohistochemistry revealed autoantibodies against autonomic nervous system structures in 5 of 12 (41.6%) of the patients. Western blot analysis showed neuronal reactivity in 11 of 12 (91.6%) patients. The authors hypothesize that CRPS can result from an autoimmune process against the sympathetic nervous system.

Received August 1, 2003. Accepted in final form June 30, 2004.

F.B. and K.S. contributed equally to this study.






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