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NEUROLOGY 2004;63:1747-1750
© 2004 American Academy of Neurology
Brief Communications

The occurrence of Guillain-Barré syndrome within families

K. Geleijns, MD, B. A. Brouwer, B. C. Jacobs, MD, PhD, J. J. Houwing-Duistermaat, PhD, C. M. van Duijn, PhD and P. A. van Doorn, MD, PhD

From the Departments of Neurology (Drs. Geleijns, Jacobs, and van Doorn, and B.A. Brouwer), Immunology (Drs. Geleijns and Jacobs), and Genetic Epidemiology (Dr. van Duijn), Erasmus Medical Center, Rotterdam; and Department of Medical Statistics and Bioinformatics (Dr. Houwing-Duistermaat), Leiden University Medical Center, The Netherlands.

Address correspondence and reprint requests to Dr. Karin Geleijns, Department of Neurology, Room Ee 2230, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands; e-mail: c.geleijns{at}erasmusmc.nl

This report describes 12 Dutch families of which at least two members have had Guillain-Barré syndrome (GBS). The authors observed an earlier onset of GBS in successive generations. The occurrence of GBS within families suggests a role for genetic factors in the pathogenesis of GBS.

Received March 11, 2004. Accepted in final form July 1, 2004.




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Correspondence:

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The occurrence of Guillain-Barré syndrome within families
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